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Titolo:
The sheep genome contributes to localization of control elements in a human gene with complex regulatory mechanisms
Autore:
Mouchel, N; Tebbutt, SJ; Broackes-Carter, FC; Sahota, V; Summerfield, T; Gregory, DJ; Harris, A;
Indirizzi:
Univ Oxford, Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS dcliffe Hosp, Oxford OX3 9DS, England Univ Otago, Dept Biochem, Dunedin, New Zealand Univ Otago Dunedin New Zealand tago, Dept Biochem, Dunedin, New Zealand
Titolo Testata:
GENOMICS
fascicolo: 1-3, volume: 76, anno: 2001,
pagine: 9 - 13
SICI:
0888-7543(200108)76:1-3<9:TSGCTL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMEMBRANE CONDUCTANCE REGULATOR; I-HYPERSENSITIVE SITES; YEAST ARTIFICIAL CHROMOSOME; CYSTIC-FIBROSIS GENE; HUMAN CFTR GENE; SEQUENCE-ANALYSIS; PROMOTER REGION; EXPRESSION; UPSTREAM; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, A Univ Oxford, Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS sp, Oxford OX3 9DS, England
Citazione:
N. Mouchel et al., "The sheep genome contributes to localization of control elements in a human gene with complex regulatory mechanisms", GENOMICS, 76(1-3), 2001, pp. 9-13

Abstract

Genes that show complex tissue-specific and temporal control by regulatoryelements located outside their promoters present a considerable challenge to identify the sequences involved. The rapid accumulation of genomic sequence information for a number of species has enabled a comparative phylogenetic approach to find important regulatory elements. For some genes, which show a similar pattern of expression in humans and rodents, genomic sequenceinformation for these two species may be sufficient. Others, such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene, show significant divergence in expression patterns between mouse and human, necessitating phylogenetic approaches involving additional species. The ovine CFTR gene has a temporal and spatial expression pattern that is very similar to that of human CFTR. Comparative genomic sequence analysis of ovine and human CFTR identified high levels of homology between the core elements in several potential regulatory elements defined as DNase I hypersensitive sites in human CFTR. These data provide a case for the power of an artiodactyl genome to contribute to the understanding of human genetic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:52:18