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Titolo:
Amplification of ribosomal RNA genes in acute myeloid leukemia
Autore:
Fonatsch, C; Nowotny, H; Pittermann-Hocker, E; Streubel, B; Jager, U; Valent, P; Buchner, T; Lechner, K;
Indirizzi:
Univ Vienna, Med Biol Inst, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Med Biol Inst, A-1090 Vienna, Austria Univ Vienna, Dept Internal Med 1, Div Hemotol & Hemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria Hanusch Hosp, Ludwig Boltzmann Inst Leukamieforsch, Vienna, Austria Hanusch Hosp Vienna Austria tzmann Inst Leukamieforsch, Vienna, Austria Hanusch Hosp, Dritte Med Abt, Vienna, Austria Hanusch Hosp Vienna Austria nusch Hosp, Dritte Med Abt, Vienna, Austria Univ Munster, Abt Innere Med A, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 nnere Med A, D-4400 Munster, Germany
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 32, anno: 2001,
pagine: 11 - 17
SICI:
1045-2257(200109)32:1<11:AORRGI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENTAL JUMPING TRANSLOCATION; IN-SITU HYBRIDIZATION; HODGKINS-DISEASE; CHROMOSOME-ABNORMALITIES; MYELODYSPLASTIC SYNDROME; ORGANIZER REGIONS; MLL GENE; REARRANGEMENTS; SEQUENCES; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fonatsch, C Univ Vienna, Med Biol Inst, Wahringer 10, A-1090 Vienna, Austria Univ Vienna Wahringer 10 Vienna Austria A-1090 ienna, Austria
Citazione:
C. Fonatsch et al., "Amplification of ribosomal RNA genes in acute myeloid leukemia", GENE CHROM, 32(1), 2001, pp. 11-17

Abstract

Gene amplification is a relatively rare event in acute myeloid leukemia (AML). Double minutes (dmin) and homogeneously staining regions are well established phenomena as cytogenetic correlates of gene amplification. Recently, however, two additional mechanisms leading to gene amplification, i.e., segmental jumping translocations and formation of ring chromosomes, have been described. We report four patients with AML, in whom bone marrow cells exhibited amplifications of ribosomal RNA (rRNA) genes in the form of ring chromosomes or a hsr. In two patients, the MILL gene, and in one patient the CBFA2 gene were shown to be co-amplified with rRNA genes. In two of the four patients, multiple copies of alpha-satellite sequences of the centromeres13 and 21, respectively, were also demonstrated. In three of the four patients, the clinical course was very aggressive, leading to death within 2-8 months. In these three patients, complex karyotype abnormalities were found, whereas the karyotype of Patient 4 was characterized only by supernumerary ring 21 chromosomes of different sizes and a trisomy 8 in half of the metaphases. Modes of origin and clinical significance of the amplification of rRNA genes are discussed. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:59:42