Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immune reconstitution in pediatric stem-cell transplantation
Autore:
Auletta, JJ; Fisher, VL;
Indirizzi:
Rainbow Babies & Childrens Hosp, Div Pediat Hematol Oncol, Cleveland, OH 44106 USA Rainbow Babies & Childrens Hosp Cleveland OH USA 44106 land, OH 44106 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: G23 - G32
SICI:
1093-9946(200108)6:<G23:IRIPST>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; VERSUS-HOST DISEASE; CORD-BLOOD TRANSPLANTATION; NECROSIS-FACTOR-ALPHA; NATURAL-KILLER-CELLS; PERIPHERAL-BLOOD; DENDRITIC CELLS; UNRELATED DONORS; CYTOKINE PRODUCTION; NK CELLS;
Keywords:
graft-versus-host disease (GVHD); hematopoietic stem-cell transplantation (Hsct); immune reconstitution; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Auletta, JJ Rainbow Babies & Childrens Hosp, Div Pediat Hematol Oncol, 11100 Euclid Ave, Cleveland, OH 44106 USA Rainbow Babies & Childrens Hosp 11100 Euclid Ave Cleveland OH USA 44106
Citazione:
J.J. Auletta e V.L. Fisher, "Immune reconstitution in pediatric stem-cell transplantation", FRONT BIOSC, 6, 2001, pp. G23-G32

Abstract

Hematopoietic stem-cell transplantation (HSCT) has successfully been used to cure many pediatric disorders. However, the immunologic alterations associated with transplantation result in profound immunodeficiencies in the transplant recipient, resulting in significant infectious morbidity and mortality. The precarious process of immune reconstitution in the transplant recipient is neither instantaneous nor complete, but influenced by multiple factors such as graft-versus-host disease (GVHD), conditioning regimen, patient age and underlying disease. Studies in pediatric HSCT have revealed unique attributes of immune recovery in pediatric transplant recipients. Futurestudies addressing these findings are needed to complement novel immunotherapies emerging from the field of transplant immunology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:33:20