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Titolo:
Nonmyeloablative hematopoietic stem cell transplantation: Transplantation for the 21(st) century
Autore:
Maris, M; Woolfrey, A; McSweeney, PA; Sandmaier, BM; Nash, RA; Georges, G; Maloney, DG; Molina, A; Chauncey, T; Yu, C; Zaucha, JM; Blume, KG; Shizuru, J; Niederwieser, D; Storb, R;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iv Washington, Seattle, WA 98195 USA Vet Adm Med Ctr, Seattle, WA 98108 USA Vet Adm Med Ctr Seattle WA USA 98108 t Adm Med Ctr, Seattle, WA 98108 USA Stanford Univ, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305Stanford Univ, Stanford, CA 94305 USA Univ Leipzig, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 niv Leipzig, D-7010 Leipzig, Germany
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: G13 - G16
SICI:
1093-9946(200108)6:<G13:NHSCTT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; TOTAL-BODY IRRADIATION; IDENTICAL LITTERMATE DOGS; PHARMACOLOGICAL IMMUNOSUPPRESSION; HOST-DISEASE; GRAFT; CHIMERISM; TRANSFUSIONS; RECIPIENTS; LEUKEMIA;
Keywords:
hematopoietic stem cells; graft-versus-leukemia effect; nonmyeloablative transplants; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Storb, R Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N,D1-100,POB 19024, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N,D1-100,POB 19024 Seattle WA USA 98109
Citazione:
M. Maris et al., "Nonmyeloablative hematopoietic stem cell transplantation: Transplantation for the 21(st) century", FRONT BIOSC, 6, 2001, pp. G13-G16

Abstract

Conventional approaches to allogeneic stem cell transplantation have used toxic high-dose conditioning therapy to achieve allogeneic engraftment and control of underlying disease. For engraftment purposes, preclinical studies and clinical observations have shown that conditioning regimens can be markedly reduced in intensity, resulting in reduced treatment toxicities. Preclinical canine studies demonstrated that the use of potent pre- and postgrafting immunosuppression allows for reduction in conditioning regimens while facilitating development of stable mixed chimerism. If attenuated conditioning regimens can be successfully translated to human stem cell transplantation, an improved safety profile will allow potentially curative treatmentto a more representative patient profile not currently offered such therapy. Mixed chimerism could prove curative of disease phenotype of various nonmalignant disturbances of the hematopoietic and immune systems. For patients with hematopoietic malignancy, spontaneous conversion to full donor hematopoeisis after stem cell transplant may prove curative by virtue of graft versus host reactions directed against the malignancy, however infusion of additional donor lymphocytes may be needed to treat persistent disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:19:56