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Titolo:
Alzheimer movement re-examined 25 years later: Is it a "disease" or a senile condition in medical nature?
Autore:
Chen, M; Fernandez, HL;
Indirizzi:
Bay Pines VA Med Ctr, Med Res Serv 151, Neurosci Res Lab, Bay Pines, FL 33744 USA Bay Pines VA Med Ctr Bay Pines FL USA 33744 Lab, Bay Pines, FL 33744 USA Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 rmacol & Therapeut, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Neurol, Tampa, FL 33612 USA Univ S FloridaTampa FL USA 33612 l Med, Dept Neurol, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Physiol & Biophys, Tampa, FL 33612 USA UnivS Florida Tampa FL USA 33612 Physiol & Biophys, Tampa, FL 33612 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: E30 - E40
SICI:
1093-9946(200108)6:<E30:AMR2YL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; DEMENTIA; THERAPY; MEMORY; RATS;
Keywords:
aging; Alzheimer; brain; amyloid; tau; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, M Bay Pines VA Med Ctr, Med Res Serv 151, Neurosci Res Lab, Bay Pines, FL 33744 USA Bay Pines VA Med Ctr Bay Pines FL USA 33744 y Pines, FL 33744 USA
Citazione:
M. Chen e H.L. Fernandez, "Alzheimer movement re-examined 25 years later: Is it a "disease" or a senile condition in medical nature?", FRONT BIOSC, 6, 2001, pp. E30-E40

Abstract

Dementia in the elderly used to be rare, but why has it become a major social threat today? There can be many potential answers, but an ultimate one is clear: the longer life expectancy today. This knowledge indicates that "advanced aging" is a primary suspect in the origin of senile dementia. If so, then why can many elderly remain healthy at the same old age? We know, for example, that elderly people commonly have a certain degree of atherosclerosis and osteoporosis, but only some of them develop severe clinical symptoms at the same age. These different outcomes generally can be explained by "risk factors" in life (exercise, diet, individual background, etc). It thus appears to be a general pattern that advanced aging (after age 80) willset the stage for various senile disorders, but risk factors largely determine the onset age as well as individual specificity of their clinical manifestations. In this context, senile disorders including senile dementia would differ fundamentally from the pathogen-caused conventional diseases (AIDS, polio, cancer, Down's, etc.) by origin, incidence, and intervention strategy. This view would call into question the current definition of senile dementia as a conventional "disease" (Alzheimer's). The term "Alzheimer's disease" originally referred to "midlife" dementia, but it is defined today to be the same medical entity as senile dementia on the basis that they bothdisplay the same hallmarks and symptoms despite their onset age difference. Now, after in-depth scrutiny, we finally come to realize that they are not the same disease, but as different as heart failure at midlife versus the"same" failure at advanced age (i.e., a conventional disease versus a senile condition). Thus, by eliminating the age difference, the new definition has converted a senile condition into a conventional "disease", thereby changing the course of its scientific inquiry to miss the main targets. This may be why after extensive studies for 25 years, the origin of senile dementia has remained an enigma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:01:59