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Titolo:
Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis
Autore:
Fleming, TP; Sheth, B; Fesenko, I;
Indirizzi:
Univ Southampton, Sch Biol Sci, Div Cell Sci, Southampton SO16 7PX, Hants,England Univ Southampton Southampton Hants England SO16 7PX 16 7PX, Hants,England
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1000 - D1007
SICI:
1093-9946(200108)6:<D1000:CAITPM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE 8-CELL BLASTOMERES; JUNCTION PROTEIN CINGULIN; INTEGRAL MEMBRANE-PROTEIN; TIGHT JUNCTION; E-CADHERIN; INTERCELLULAR-JUNCTIONS; BETA-CATENIN; COMPACTION; ZO-1; EXPRESSION;
Keywords:
cell adhesion; E-cadherin; tight junction; desmosome; trophectoderm; blastocyst; inner cell mass; Icm; epithelium; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Fleming, TP Univ Southampton, Sch Biol Sci, Div Cell Sci, Basett Crescent E, Southampton SO16 7PX, Hants, England Univ Southampton Basett Crescent E Southampton Hants England SO16 7PX
Citazione:
T.P. Fleming et al., "Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis", FRONT BIOSC, 6, 2001, pp. D1000-D1007

Abstract

Cell adhesion plays a critical role in the differentiation of the trophectoderm epithelium and the morphogenesis of the blastocyst. In the mouse embryo, E-cadherin mediated adhesion initiates at compaction at the 8-cell stage, regulated post-translationally via protein kinase C and other signallingmolecules. E-cadherin adhesion organises epithelial polarisation of blastomeres at compaction. Subsequently, the proteins of the epithelial tight junction are expressed and assemble at the apicolateral contact region betweenouter blastomeres in three phases, culminating at the 32-cell stage when blastocoel cavitation begins. Cell adhesion events also coordinate the cellular allocation and spatial segregation of the inner cell mass (ICM) of the blastocyst, and the maintenance of epithelial (trophectoderm) and non-epithelial (ICM) phenotypes during early morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:14:14