Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic organization of the human MHC class III region
Autore:
Milner, CM; Campbell, RD;
Indirizzi:
Univ Oxford, Dept Biochem, MRC, Immunochem Unit, Oxford OX1 3QU, England Univ Oxford Oxford England OX1 3QU unochem Unit, Oxford OX1 3QU, England UK HGMP Resource Ctr, Cambridge, England UK HGMP Resource Ctr Cambridge England Resource Ctr, Cambridge, England
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D914 - D926
SICI:
1093-9946(200108)6:<D914:GOOTHM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; TUMOR-NECROSIS-FACTOR; HEAT-SHOCK PROTEIN; CASEIN KINASE-II; ADRENAL-SPECIFIC TRANSCRIPTION; HUMAN LYSOSOMAL NEURAMINIDASE; STEROID 21-HYDROXYLASE GENES; GLYCOSYLATION END-PRODUCTS; MAMMARY EPITHELIAL-CELLS; TRANSFER RNA-SYNTHETASE;
Keywords:
MHC class III region; hsp70; lysophosphatidic acetyl transferase; novel Ly-6 ssuperfamily members; novel IgG superfamily members; candidate autoimmune disease susceptibility genes; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Milner, CM Univ Oxford, Dept Biochem, MRC, Immunochem Unit, S Parks Rd, Oxford OX1 3QU, England Univ Oxford S Parks Rd Oxford England OX1 3QU OX1 3QU, England
Citazione:
C.M. Milner e R.D. Campbell, "Genetic organization of the human MHC class III region", FRONT BIOSC, 6, 2001, pp. D914-D926

Abstract

The human major histocompatibility complex (MHC), or human leukocyte antigen (HLA) region, encompasses over 4 Mb of DNA on the short arm of chromosome 6 and is traditionally divided into the class I, class II and class III regions. The MHC has now been entirely sequenced and similar to 220 genes have been defined of which similar to 62 are in the class III region. It is becoming clear that many of the latter encode proteins that are likely to beinvolved in the immune and inflammatory responses. The MHC is known to contribute to a large number of immune-related disorders including insulin dependent diabetes mellitus, rheumatoid arthritis, common variable immunodeficiency and IgA deficiency and there is growing evidence that genes within the class III region are important in determining susceptibility to many of these complex conditions. Genes in the class III region have also been implicated in a number of non-immune-related diseases such as congenital adrenalhyperplasia and sialidosis. Now that the full gene content of the class III region is known the stage is set for the identification and characterisation of candidate disease genes, which will allow greater understanding of the causes of many MHC-linked diseases and thus aid the development of improved treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:51:10