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Titolo:
Carotenoids as scavengers of free radicals in a Fenton reaction: Antioxidants or pro-oxidants?
Autore:
Polyakov, NE; Leshina, TV; Konovalova, TA; Kispert, LD;
Indirizzi:
Univ Alabama, Dept Chem, Tuscaloosa, AL 35476 USA Univ Alabama TuscaloosaAL USA 35476 Dept Chem, Tuscaloosa, AL 35476 USA Russian Acad Sci, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia Russian Acad Sci Novosibirsk Russia 630090 t, Novosibirsk 630090, Russia
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 3, volume: 31, anno: 2001,
pagine: 398 - 404
SICI:
0891-5849(20010801)31:3<398:CASOFR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN OXIDATION; BETA-CAROTENE; LIPID-PEROXIDATION; WATER; LDL; TOCOPHEROL;
Keywords:
carotenoids; free radicals; antioxidant activity; pro-oxidant activity; Fenton reaction; spin trapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kispert, LD Univ Alabama, Dept Chem, POB 870336, Tuscaloosa, AL 35476 USA Univ Alabama POB 870336 Tuscaloosa AL USA 35476 , AL 35476 USA
Citazione:
N.E. Polyakov et al., "Carotenoids as scavengers of free radicals in a Fenton reaction: Antioxidants or pro-oxidants?", FREE RAD B, 31(3), 2001, pp. 398-404

Abstract

The spin trapping EPR technique was used to study the influence of carotenoids (beta -carotene, 8'-apo-beta -caroten-8'-al, canthaxanthin, and ethyl 8'-apo-beta -caroten-8'-oate) on the yield of free radicals in the Fenton reaction (Fe2+ + H2O2 --> Fe3+ + (OH)-O-. + -OH) in the organic solvents, DMSO, and methanol. DMPO and PBN were used as spin trapping agents. It was demonstrated that carotenoids could increase or decrease the total yield of free radicals depending on the oxidation potential of the carotenoids and the nature of the radicals. A reaction mechanism is suggested which includes the reduction of Fe3+ to Fe2+ by carotenoids. The effectiveness of this carotenoid-driven Fenton reaction increases with a decrease of the scavenging rates for free radicals and with decreasing oxidation potentials of carotenoids. (C) 2001 Elsevier Science Inc.

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Documento generato il 18/09/20 alle ore 09:19:08