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Titolo:
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain
Autore:
Andorn, AC; Pappolla, MA;
Indirizzi:
Univ Texas, Med Branch, Dept Psychiat & Behav Sci, Galveston, TX 77555 USAUniv Texas Galveston TX USA 77555 at & Behav Sci, Galveston, TX 77555 USA Univ S Alabama, Med Ctr, Dept Pathol, Mobile, AL USA Univ S Alabama Mobile AL USA abama, Med Ctr, Dept Pathol, Mobile, AL USA Univ S Alabama, Med Ctr, Dept Neurol, Mobile, AL USA Univ S Alabama Mobile AL USA abama, Med Ctr, Dept Neurol, Mobile, AL USA
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 3, volume: 31, anno: 2001,
pagine: 315 - 320
SICI:
0891-5849(20010801)31:3<315:CILPIY>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCORBIC-ACID; HYDROGEN-PEROXIDE; RECEPTOR-BINDING; BIOGENIC-AMINES; END-PRODUCTS; DOPAMINE; METABOLITES; ANTIOXIDANT; IRON; SEROTONIN;
Keywords:
catecholamines; serotonin; lipid peroxidation; ascorbate; human brain; aging; Alzheimer's disease; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Andorn, AC Univ Texas, Med Branch, Dept Psychiat & Behav Sci, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd Galveston TX USA 77555 n, TX 77555 USA
Citazione:
A.C. Andorn e M.A. Pappolla, "Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain", FREE RAD B, 31(3), 2001, pp. 315-320

Abstract

Some catecholamines and indolamines inhibit lipid peroxidation. Recent studies indicate that catecholaminergic inhibition of lipid peroxidation may be receptor mediated in vivo and in cell cultures. Because oxidative stress is one of the hypothesized pathogenic mechanisms for neurodegenerative diseases, including Alzheimer's disease (AD), we hypothesized that catecholaminergic and indolaminergic inhibition of lipid peroxidation would be altered in AD as compared to age-matched non-AD. To test this hypothesis we studiedthe effect of a variety of neurotransmitters and their antagonists on ascorbate-stimulated lipid peroxidation in membrane fragment preparations derived from postmortem human brain. In this in vitro system, the inhibition of lipid peroxidation by dopamine and serotonin did not appear to be receptor mediated. Further, our findings indicate that there is no apparent effect of age or AD on the inhibition of lipid peroxidation by catecholaminergic and indolaminergic, agents. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:05:10