Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of toxaphene on the immune system of cynomolgus (Macaca fascicularis) monkeys
Autore:
Tryphonas, H; Arnold, DL; Bryce, F; Huang, J; Hodgen, M; Ladouceur, DT; Fernie, S; Lepage-Parenteau, M; Hayward, S;
Indirizzi:
Hlth Canada, Hlth Prod & Food Branch, Bur Chem Safety, Toxicol Res Div, Ottawa, ON KA1 0L2, Canada Hlth Canada Ottawa ON Canada KA1 0L2 Res Div, Ottawa, ON KA1 0L2, Canada Hlth Canada, Hlth Prod & Food Branch, Lab Communicable Dis Ctr, Ottawa, ONKA1 0L2, Canada Hlth Canada Ottawa ON Canada KA1 0L2 e Dis Ctr, Ottawa, ONKA1 0L2, Canada Hlth Canada, Hlth Prod & Food Branch, Anim Resources Div, Ottawa, ON KA1 0L2, Canada Hlth Canada Ottawa ON Canada KA1 0L2 rces Div, Ottawa, ON KA1 0L2, Canada Hlth Canada, Hlth Prod & Food Branch, Chem Stat Sect, Bur Biostat & Comp Applicat,Food Directorate, Ottawa, ON KA1 0L2, Canada Hlth Canada Ottawa ONCanada KA1 0L2 ectorate, Ottawa, ON KA1 0L2, Canada
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 9, volume: 39, anno: 2001,
pagine: 947 - 958
SICI:
0278-6915(200109)39:9<947:EOTOTI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARINE FOOD-CHAINS; ORGANOCHLORINE CONTAMINANTS; PCB AROCLOR-1254; PARAMETERS;
Keywords:
toxaphene immunotoxicity; toxaphene effects in monkeys; pesticide immunotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tryphonas, H Hlth Canada, Hlth Prod & Food Branch, Bur Chem Safety, Toxicol Res Div, PL2202D1, Ottawa, ON KA1 0L2, Canada Hlth Canada PL2202D1 OttawaON Canada KA1 0L2 KA1 0L2, Canada
Citazione:
H. Tryphonas et al., "Effects of toxaphene on the immune system of cynomolgus (Macaca fascicularis) monkeys", FOOD CHEM T, 39(9), 2001, pp. 947-958

Abstract

Toxaphene, dissolved in glycerol/corn oil, was administered at 0.1, 0.4 or0.8 mg/kg body weight/day in gelatin capsules to groups of 10 young adult female cynomolgus monkeys (Macaca fascicularis), while a group of five malemonkeys (Macaca fascicularis) received 0.8 mg/kg body weight/day. Control male (a group of five) and female (a group of 10) monkeys ingested the glycerol/corn oil vehicle only. Treatment continued for 75 weeks. Testing for immune effects was initiated at 33 weeks of treatment. Immunization was initiated at 44 weeks of treatment. Pairwise comparisons between each of the treated female groups to the control indicated that the mean primary (post-immunization weeks 1-4) and secondary (post-immunization weeks 5-8) anti-SRBCIgM responses were significantly reduced at the 0.4 and 0.8 mg/kg body weight/day doses compared to the control (P less than or equal to0.05). The mean primary (post-immunization weeks 1-4) anti-SRBC I.-G response was significantly reduced compared to the control (P less than or equal to0.05), while the secondary (post-immunization weeks 5-8) anti-SRBC IgG was not significantly affected by treatment (P >0.05). The mean anti-tetanus toxoid IgG response in the 0.8 mg/kg body weight/day dose group The mean primary anti-SRBC (IgM) response in the treated males was significantly different from thecontrol (P <0.05), while the primary anti-SRBC IgG response was not affected by treatment. The mean absolute B-lymphocyte numbers in the female groupadministered 0.8 mg/kg of toxaphene was significantly reduced compared to the control (P less than or equal to0.05). All other parameters including the natural killer cell activity, the delayed-type hypersensitivity response, the lymphoproliferative response of peripheral blood leukocytes to the mitogens Con A and PWM and the serum cortisol levels were not affected significantly by treatment (P >0.05). The no-observed-adverse-effect level (NOAEL) for the female monkeys based on the toxaphene effects on humoral immunitywas 0.1 mg/kg body weight/day. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:37:08