Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen, Bet v 1
Autore:
Vrtala, S; Hirtenlehner, K; Susani, M; Akdis, M; Kussebi, F; Akdis, CA; Blaser, K; Hufnagl, P; Binder, BR; Politou, A; Pastore, A; Vangelista, L; Sperr, WR; Semper, H; Valent, P; Ebner, C; Kraft, D; Valenta, R;
Indirizzi:
Univ Vienna, Vienna Gen Hosp, Sch Med, Dept Pathophysiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Pathophysiol, A-1090 Vienna, Austria Austrian Acad Sci, Inst Mol Biol, A-5020 Salzburg, Austria Austrian Acad Sci Salzburg Austria A-5020 Biol, A-5020 Salzburg, Austria Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res Davos Switzerland CH-7270 s, Switzerland Univ Vienna, Sch Med, Dept Vasc Biol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Vasc Biol, A-1090 Vienna, Austria Univ Crete, Sch Med, Iraklion 71100, Greece Univ Crete Iraklion Greece 71100 Crete, Sch Med, Iraklion 71100, Greece Natl Inst Med Res, Mol Struct Div, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ct Div, London NW7 1AA, England Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy Int Ctr Genet Engn& Biotechnol Trieste Italy I-34012 012 Trieste, Italy Univ Vienna, Vienna Gen Hosp, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria
Titolo Testata:
FASEB JOURNAL
fascicolo: 9, volume: 15, anno: 2001,
pagine: NIL_101 - NIL_119
SICI:
0892-6638(200107)15:9<NIL_101:GEOAHT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL CLONES; QUANTITATIVE IGE INHIBITION; ANTIGEN-PRESENTING CELLS; FC-EPSILON-RI; IMMUNOLOGICAL CHANGES; CROSS-REACT; WILD-TYPE; IMMUNOTHERAPY; BET-V-1; EPITOPES;
Keywords:
type I allergy; vaccine; genetic engineering;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Valenta, R Univ Vienna, Vienna Gen Hosp, Sch Med, Dept Pathophysiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 ria
Citazione:
S. Vrtala et al., "Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen, Bet v 1", FASEB J, 15(9), 2001, pp. NIL_101-NIL_119

Abstract

An estimated 100 million individuals suffer from birch pollen allergy. Specific immunotherapy, the only curative allergy treatment, can cause life-threatening anaphylactic side effects. Here, we report the genetic engineering of a recombinant trimer consisting of three covalently linked copies of the major birch pollen allergen, Bet v 1. The trimer exhibited profoundly reduced allergenic activity but contained similar secondary structures such as Bet v 1 wild type, Bet v 1-specific B cell and T-cell epitopes, and induced Th1 cytokine release. As immunogen, rBet v 1 trimer induced IgG antibodies, which blocked patients' IgE binding to Bet v 1 and related allergens. Thus, rBet v 1 trimer represents a novel hypoallergenic vaccine prototype for treatment of one of the most frequent allergy forms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:59:24