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Titolo:
Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats
Autore:
McTavish, SFB; Raumann, B; Cowen, PJ; Sharp, T;
Indirizzi:
Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England Univ Oxford Oxford England OX1 3QT pt Pharmacol, Oxford OX1 3QT, England Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England Univ Oxford Oxford England rneford Hosp, Dept Psychiat, Oxford, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 424, anno: 2001,
pagine: 115 - 119
SICI:
0014-2999(20010720)424:2<115:TDATBS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID MIXTURE; DOPAMINE; INVIVO; BRAIN; NORADRENALINE; PHENYLALANINE; INHIBITION; STRIATUM; RELEASE; D-1;
Keywords:
tyrosine depletion; dopamine; amphetamine; cocaine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Sharp, T Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England Univ Oxford Mansfield Rd Oxford England OX1 3QT OX1 3QT, England
Citazione:
S.F.B. McTavish et al., "Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats", EUR J PHARM, 424(2), 2001, pp. 115-119

Abstract

Neurochemical studies show that a tyrosine-free amino acid mixture depletes brain tyrosine and decreases dopamine synthesis and release. Here, we tested whether such a mixture would reduce the behavioural effects of amphetamine and other psychostimulants. A tyrosine-free amino acid mixture decreased the behavioural activation induced by both D-amphetamine (2 mg/kg s.c.) and cocaine (2 mg/kg s.c.). In contrast, the activation induced by the dopamine agonist, apomorphine (0.75 and 5 mg/kg s.c.), or the 5-hydroxytryptamine releasing agent, p-chloroamphetamine (2 mg/ka s.c.) was not altered. These findings provide behavioural evidence that tyrosine-free amino acid mixtures reduce presynaptic dopamine function in the brain. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 03:32:23