Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities
Autore:
Karakurt, A; Dalkara, S; Ozalp, M; Ozbey, S; Kendi, E; Stables, JP;
Indirizzi:
Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 ceut Chem, TR-06100 Ankara, Turkey Hacettepe Univ, Fac Pharm, Pharmaceut Microbiol Dept, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 biol Dept, TR-06100 Ankara, Turkey Hacettepe Univ, Fac Engn, Dept Engn Phys, TR-06532 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06532 Engn Phys, TR-06532 Ankara, Turkey NINDS, Epilepsy Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA20892 Epilepsy Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 5, volume: 36, anno: 2001,
pagine: 421 - 433
SICI:
0223-5234(200105)36:5<421:SOS1OA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGENTS;
Keywords:
oxime and oxime ethers; (arylalkyl)imidazoles; anticonvulsant activity; antimicrobial activity; E/Z isomers; X-ray crystallography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Dalkara, S Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 TR-06100 Ankara, Turkey
Citazione:
A. Karakurt et al., "Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities", EUR J MED C, 36(5), 2001, pp. 421-433

Abstract

In this study, oxime and oxime ether derivatives of anticonvulsant nafimidone [1-(2-naphthyl)-2-(imidozole-1-yl)ethanone] were prepared as potential anticonvulsant compounds. Nafimidone oxime was synthesized by the reaction of nafimidone and hydroxylamine hydrochloride. O-Alkylation of the oxime byvarious alkyl halides gave the oxime ether derivatives. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazole (scMet) tests in mice and rats according to procedures of the Antiepileptic Drug Development (ADD) program of the National Institutes of Health (NIH). In addition to anticonvulsant evaluation, compounds were also screened for possible antibacterial and antifungal activities because of the structural resemblance to the azole antifungals, especially to oxiconazole. All compounds were evaluated against three human pathogenic fungi and four bacteria using the microdilution method. Most of the compounds exhibited both anticonvulsant and antimicrobial activities; the 0-alkyl substituted compounds (2, 3, 4 and 5) were found to be more active than the O-arylalkyl substituted compounds in both screening paradigms. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:15:57