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Titolo:
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
Autore:
Zuccotto, F; Zvelebil, M; Brun, R; Chowdhury, SF; Di Lucrezia, R; Leal, I; Maes, L; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH;
Indirizzi:
Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales Univ Wales Coll Cardiff Cardiff S Glam Wales CF10 3XF 3XF, S Glam, Wales Ludwig Inst Canc Res, London W1P 8BT, England Ludwig Inst Canc Res London England W1P 8BT Res, London W1P 8BT, England Swiss Trop Inst, CH-4002 Basel, Switzerland Swiss Trop Inst Basel Switzerland CH-4002 st, CH-4002 Basel, Switzerland CSIC, Inst Parasitol & Biomed, E-18001 Granada, Spain CSIC Granada SpainE-18001 st Parasitol & Biomed, E-18001 Granada, Spain Tibotec NV, B-2800 Mechelen, Belgium Tibotec NV Mechelen Belgium B-2800Tibotec NV, B-2800 Mechelen, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 5, volume: 36, anno: 2001,
pagine: 395 - 405
SICI:
0223-5234(200105)36:5<395:NIOTCD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESIGN; LEISHMANIA; RHODESIENSE; GAMBIENSE; BRUCEI;
Keywords:
drug design; docking; database searching; parasitic diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gilbert, IH Univ Wales Coll Cardiff, Welsh Sch Pharm, Redwood Bldg,King Edward VII Ave, Cardiff CF10 3XF, S Glam, Wales Univ Wales Coll Cardiff Redwood Bldg,King Edward VII Ave Cardiff S Glam Wales CF10 3XF
Citazione:
F. Zuccotto et al., "Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase", EUR J MED C, 36(5), 2001, pp. 395-405

Abstract

There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a very successful drug targetin a number of diseases and we decided to investigate it as a potential drug target for Chagas' disease. A homology model of the enzyme was used to search the Cambridge Structural Database using the program DOCK 3.5. Compounds were then tested against the enzyme and the whole parasite. Compounds were also screened against the related parasite, Trypanosoma brucei. (C) 2001Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:10:47