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Titolo:
Interstitial lung disease induced by endogenous Candida albicans
Autore:
Schreiber, J; Goring, HD; Rosahl, W; Struben, C; Lakotta, W; Amthor, M;
Indirizzi:
Municipal Hosp Dessau, Dept Pulmonol, D-06822 Dessau, Germany Municipal Hosp Dessau Dessau Germany D-06822 ol, D-06822 Dessau, Germany Municipal Hosp Dessau, Dept Dermatol & Immunol, Rotenburg, Germany Municipal Hosp Dessau Rotenburg Germany l & Immunol, Rotenburg, Germany Inst Pathol, Rotenburg, Germany Inst Pathol Rotenburg GermanyInst Pathol, Rotenburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF MEDICAL RESEARCH
fascicolo: 2, volume: 6, anno: 2001,
pagine: 71 - 74
SICI:
0949-2321(20010228)6:2<71:ILDIBE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERSENSITIVITY PNEUMONITIS; IGA;
Keywords:
interstitial lung disease; Candida albicans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schreiber, J Municipal Hosp Dessau, Dept Pulmonol, Auenweg 38, D-06822 Dessau, Germany Municipal Hosp Dessau Auenweg 38 Dessau Germany D-06822 many
Citazione:
J. Schreiber et al., "Interstitial lung disease induced by endogenous Candida albicans", EUR J MED R, 6(2), 2001, pp. 71-74

Abstract

We report on a 64-year old woman with an interstitial lung disease which had characteristics of hypersensitivity pneumonitis. Severe febrile attacks with impairment of ventilation and diffuse poorly defined radiodensities and ground glass opacities on chest x-ray occured repeatedly. Laboratory datashowed hyoxemia, leukopenia and circulating Candida albicans (C.a.)-antigen. Bronchoalveolar lavage revealed an increase in neutrophils. Transbronchial biopsies showed lymphocytic alveolitis, bronchiolitis obliterans and epitheloid cell granulomas. IgG and IgA and the lymphocyte proliferation assaywere positive with C.a.-antigen. C.a. was detected in the feces. Intradermal skin test with C.a. showed a positive immediate and late phase reaction and inhalative provocation test with C.a.-antigen was positive. After antimycotic treatment the symptoms resolved completely and long-lasting. We conclude that the disease was induced by C.a.-antigen reaching the lungs from the intestinal tract via the bloodstream.

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Documento generato il 02/04/20 alle ore 02:47:49