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Titolo:
Vasoreactivity of arterial grafts in the patient with diabetes mellitus: investigations on internal thoracic artery and radial artery conduits
Autore:
Wendler, O; Landwehr, P; Bandner-Risch, D; Georg, T; Schafers, HJ;
Indirizzi:
Univ Hosp, Dept Thorac & Cardiovasc Surg, Homburg, Germany Univ Hosp Homburg Germany pt Thorac & Cardiovasc Surg, Homburg, Germany Univ Hosp, Inst Med Biometr Epidemiol & Med Informat, Homburg, Germany Univ Hosp Homburg Germany tr Epidemiol & Med Informat, Homburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 305 - 311
SICI:
1010-7940(200108)20:2<305:VOAGIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; MAMMARY ARTERY; GASTROEPIPLOIC ARTERIES; CORONARY; BYPASS; REVASCULARIZATION; SURGERY; DISEASE;
Keywords:
arteries; endothelium; radial artery; internal thoracic artery; coronary artery bypass surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Wendler, O Univ Hosp, Dept Thorac & Cardiovasc Surg, Homburg, Germany UnivHosp Homburg Germany Cardiovasc Surg, Homburg, Germany
Citazione:
O. Wendler et al., "Vasoreactivity of arterial grafts in the patient with diabetes mellitus: investigations on internal thoracic artery and radial artery conduits", EUR J CAR-T, 20(2), 2001, pp. 305-311

Abstract

Objective: Arterial revascularization with either internal thoracic artery(ITA) or radial artery (RA) appears to be particularly attractive in diabetic patients. Previous investigations have shown that endothelial dysfunction and artherosclerosis are seen more often in these patients. The aim of this study was to compare the vasoreactive properties of ITA and RA grafts in diabetic and non-diabetic patients. Methods: Arterial rings were harvested from 57 patients who underwent complete arterial revascularization. The patients were divided into a nondiabetic group (I: n = 30) and patients withdiabetes mellitus (II: n = 27). Arterial rings of the ITA (I: n = 30; II: n = 27) and RA (I: n = 28; II: n = 19) were mounted on a strain gauge in oxygenated, normothermic Krebs's-Henseleit solution at optimal resting tension. With KCL (80 mM) serving as the control, assessment of force of contraction (norepinephrine), endothelium-dependent relaxation (acetylcholine) and smooth muscle-dependent relaxation (glyceroltrinitrate) were obtained. Results: After KCL, the RA showed a trend to lower maximum contraction forces in diabetics (I: 76 +/- 25 mN; II: 69 +/- 29 mN), which was pronounced in patients with diabetes of more than 10 years duration (55 +/- 23 mN; P = 0.1). Maximum contraction force of the ITA was similar in both groups (I: 41 +/- 20 mN; II: 34 +/- 19 mN) and not influenced by the duration of diabetes. The two groups showed no significant differences of the relative vasoconstriction after norepinephrine in RA (I: 53 +/- 18%; II: 61 +/- 19%) and ITA rings (I: 70 +/- 23%; II: 69 +/- 25%). Also, endothelium-dependent relaxation with acetylcholine in RA (I: 53 +/- 14%; II: 57 +/- 16%) and ITA rings (I: 42 +/- 17%; II: 44 +/- 20%), and smooth muscle relaxation with glyceroltrinitrate of RA (I: 72 +/- 8%; II: 73 +/- 12%) and ITA rings (I: 64 +/- 12%;II: 58 +/- 20%) was comparable in both groups. No influence of duration ofthe diabetic disease was noted. Conclusions: Although RA rings of patientswith a long duration of diabetes have decreased maximum contraction forces, their relative vasoconstriction after norepinephrine, endothelium-dependent relaxation and smooth muscle relaxation was similar to non-diabetic patients. We thus conclude that the RA is an arterial conduit in the patient with diabetes mellitus.(C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:34:21