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Titolo:
Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable angina - Evaluation by N-13-ammonia positron emission tomography
Autore:
Masuda, D; Nohara, R; Hirai, T; Kataoka, K; Chen, LG; Hosokawa, R; Inubushi, M; Tadamura, E; Fujita, M; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan Kyoto Univ Kyoto Japan Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan Kyoto Univ, Grad Sch Med, Dept Nucl Med, Kyoto, Japan Kyoto Univ Kyoto Japan Univ, Grad Sch Med, Dept Nucl Med, Kyoto, Japan
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 16, volume: 22, anno: 2001,
pagine: 1451 - 1458
SICI:
0195-668X(200108)22:16<1451:EECIMP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHEAR-STRESS; BLOOD-FLOW; EXERCISE; INFARCTION; PRESSURE; PECTORIS;
Keywords:
enhanced external counterpulsation; ischaemic heart disease; N-13-ammonia positron emission tomography; myocardial perfusion; coronary flow reserve; endothelial function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R 54 Shogoin Kawahara Sakyo, Kyoto 6068507, Japan 54 Shogoin Kawahara Sakyo Kyoto Japan 6068507 o 6068507, Japan
Citazione:
D. Masuda et al., "Enhanced external counterpulsation improved myocardial perfusion and coronary flow reserve in patients with chronic stable angina - Evaluation by N-13-ammonia positron emission tomography", EUR HEART J, 22(16), 2001, pp. 1451-1458

Abstract

Aims The mechanism by which enhanced external counterpulsation therapy exerts its beneficial effects on chronic and symptomatic stable angina is largely unknown. To clarify the mechanism of action of enhanced external counterpulsation, we used N-13-ammonia positron emission tomography to evaluate myocardial perfusion. Methods and Results This was not a randomized controlled study. Eleven patients (eight male, age: 61.6 +/-9.7) with angina pectoris underwent enhanced external counterpulsation therapy for 35 1 h sessions. They underwent a treadmill exercise test and N-13-ammonia positron emission tomography, both at rest and with dipyridamole; before and after enhanced external counterpulsation therapy. Neurohumoral factors and nitric oxide were also evaluated. Myocardial perfusion increased at rest after therapy (0.69 +/-0.27 to 0.85+/-0.47 ml.min(-1).g(-1), P<0.05). In ischaemic regions, particularly the anterior region, myocardial perfusion at rest and with dipyridamole and coronary flow reserve improved significantly after therapy (at rest: 0.71<plus/minus>0.26 to 0.86 +/-0.31; P<0.05, with dipyridamole: 1.26<plus/minus>0.65 to 1.84 +/-0.94; P<0.02, coronary flow reserve: 1.75<plus/minus>0.24 to 2.08 +/-0.28; P<0.04). Exercise time was prolonged and the time to 1-mm ST depression improved markedly (P<0.01). After therapy, nitric oxide levels increased (P<0.02) and neurohumoral factors decreased. Conclusions Enhanced external counterpulsation therapy improved myocardialperfusion at rest and with dipyridamole and was associated with an increased exercise tolerance with N-13-ammonia positron emission tomography and increased nitric oxide levels. These results suggest that one of the enhancedexternal counterpulsation mechanisms is development and recruitment of collateral vessels. (Eur Heart J 2001; 22: 1451-1458, doi:10.1053/euhj.2000.2545) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 02:34:39