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Titolo:
High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases
Autore:
Eriksson, K; Peltola, J; Keranen, T; Haapala, AM; Koivikko, M;
Indirizzi:
Univ Tampere, Tampere Univ Hosp, Dept Pediat, Pediat Neurol Unit, FIN-33521 Tampere, Finland Univ Tampere Tampere Finland FIN-33521 Unit, FIN-33521 Tampere, Finland Univ Tampere, Tampere Univ Hosp, Sch Med, FIN-33521 Tampere, Finland Univ Tampere Tampere Finland FIN-33521 h Med, FIN-33521 Tampere, Finland Univ Tampere, Tampere Univ Hosp, Dept Neurol, FIN-33521 Tampere, Finland Univ Tampere Tampere Finland FIN-33521 eurol, FIN-33521 Tampere, Finland Univ Tampere, Tampere Univ Hosp, Ctr Lab Med, Dept Clin Microbiol, FIN-33521 Tampere, Finland Univ Tampere Tampere Finland FIN-33521 obiol, FIN-33521 Tampere, Finland
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 46, anno: 2001,
pagine: 129 - 137
SICI:
0920-1211(200108)46:2<129:HPOAAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACTABLE CHILDHOOD EPILEPSY; GLUTAMATE-RECEPTOR GLUR3; RASMUSSENS-ENCEPHALITIS; INFANTILE SPASMS; AUTOANTIBODIES; PREDNISONE; THERAPY; ACTH;
Keywords:
epilepsy; childhood; immunology; antiphospholipid antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Eriksson, K Univ Tampere, Tampere Univ Hosp, Dept Pediat, Pediat Neurol Unit, POB 2000, FIN-33521 Tampere, Finland Univ Tampere POB 2000 Tampere Finland FIN-33521 pere, Finland
Citazione:
K. Eriksson et al., "High prevalence of antiphospholipid antibodies in children with epilepsy: a controlled study of 50 cases", EPILEPSY R, 46(2), 2001, pp. 129-137

Abstract

Evidence of immune system aberrations in patients with epilepsy includes antiphospholipid antibody positivity in adult patients with epilepsy with a prevalence of 19-26% and in 13% of children with partial epilepsy. Also immunoglobulin A deficiency has been reported to exist in up to 25%, of epilepsy patients. The possible role of immune mechanisms in the pathogenesis of childhood epilepsy is clinically supported by the effectiveness of immunomodulatory treatments in cases with catastrophic childhood epilepsies. We analyzed a set of various autoantibodies in 50 consecutive children with epilepsy and in 20 healthy control subjects. None of the children had any clinical signs of immune system disorders. The main result was a significantly (P= 0.011) higher prevalence of antiphospholipid antibodies in the study group (44%) compared with controls (10%). These antibodies were unexpectedly common (71-80%) in children with multiple seizure types associated often with symptomatic etiology, early onset and high frequency of seizures. There was no evidence of the antiphospholipid positivity being induced by certain AEDs (e.g. phenytoin or carbamazepine). Even though the significance of these autoantibodies remains unknown, their increased prevalence indicates that immune system mediated mechanisms may have a role in the manifestation ofepilepsy in some children. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:58:26