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Titolo:
Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels
Autore:
Rubin, BS; Murray, MK; Damassa, DA; King, JC; Soto, AM;
Indirizzi:
Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Boston, MA 02111 USA TuftsUniv Boston MA USA 02111 Anat & Cellular Biol, Boston, MA 02111 USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 7, volume: 109, anno: 2001,
pagine: 675 - 680
SICI:
0091-6765(200107)109:7<675:PETLDO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE RATS; ESTROGENIC CHEMICALS; DISRUPTING CHEMICALS; SEXUAL-BEHAVIOR; NERVOUS-SYSTEM; IN-VITRO; ESTRADIOL; GROWTH; SERUM; DIETHYLSTILBESTROL;
Keywords:
bisphenol A; body weight; BPA; development; endocrine disruptors; environmental estrogens; estrous cycles; reproductive function; xenoestrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Soto, AM Tufts Univ, Sch Med, Dept Anat & Cellular Biol, 136 Harison Ave, Boston, MA 02111 USA Tufts Univ 136 Harison Ave Boston MA USA 02111 ston, MA 02111 USA
Citazione:
B.S. Rubin et al., "Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels", ENVIR H PER, 109(7), 2001, pp. 675-680

Abstract

The nonsteroidal estrogenic compound bisphenol A (BPA) is a monomer used in the manufacture of polycarbonate plastics and resins. BPA may be ingestedby humans as it reportedly leaches from the lining of tin cans into foods,from dental sealants into saliva, and from polycarbonate bottles into their contents. Because BPA is weakly estrogenic-approximately 10,000-fold lesspotent than 17 beta -estradiol-current environmental exposure levels have been considered orders of magnitude below the dose required for adverse effects on health. Herein we demonstrate measurable effects on the offspring of Sprague-Dawley female rats that were exposed, via their drinking water, to approximately 0.1 mg BPA/kg body weight (bw)/day (low dose) or 1.2 mg BPA/kg bw/day (high dose) from day 6 of pregnancy through the period of lactation. Offspring exposed to BPA exhibited an increase in body weight that wasapparent soon after birth and continued into adulthood. In addition, female offspring exposed perinatally to the high dose of BPA exhibited altered patterns of estrous cyclicity and decreased levels of plasma luteinizing hormone (LH) in adulthood. Administration of neither the doses of BPA that caused effects during perinatal exposure nor a 10-fold higher dose was able toevoke a uterotropic response in ovariectomized postpubertal females. Thesedata indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:58:58