Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei
Autore:
Abbott, CR; Rossi, M; Wren, AM; Murphy, KG; Kennedy, AR; Stanley, SA; Zollner, AN; Morgan, DGA; Morgan, I; Ghatei, MA; Small, CJ; Bloom, SR;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ne Unit, London W12 0NN, England
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 8, volume: 142, anno: 2001,
pagine: 3457 - 3463
SICI:
0013-7227(200108)142:8<3457:EOAORF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; NEUROPEPTIDE-Y; CART PEPTIDES; RAT; NEURONS; LEPTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Bloom, SR Hammersmith Hosp, Imperial Coll Sch Med, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ondon W12 0NN, England
Citazione:
C.R. Abbott et al., "Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei", ENDOCRINOL, 142(8), 2001, pp. 3457-3463

Abstract

Cocaine- and amphetamine-regulated transcript is expressed in hypothalamicregions involved in the central control of food intake. Previous data haveimplicated cocaine- and amphetamine-regulated transcript as an anorectic peptide. We studied the effect of the active fragment of cocaine- and amphetamine-regulated transcript, cocaine- and amphetamine-regulated transcript-(55-102), on feeding when injected into discrete nuclei of the hypothalamus. Cocaine- and amphetamine-regulated transcript-(55-102) (0.04 nmol) elicited a delayed, but significant, increase in feeding in 24-h fasted rats afterinjection into the ventromedial nucleus (1-2 h, 261 +/- 60% of control; P < 0.05) and arcuate nucleus (1-2 h, 225 +/- 38% of control; P < 0.05) of the hypothalamus. Administration of a higher dose of cocaine- and amphetamine-regulated transcript-(55-102) (0.2 nmol) elicited a significant increase in feeding after injection into the ventromedial nucleus (1-2 h, 1253 +/- 179% of control; P < 0.001), arcuate nucleus (1-2 h, 265 43% of control; P < 0.05), paraventricular nucleus (2-4 h food intake, 186 +/- 29% of control; P < 0.05), lateral hypothalamic area (2-4 h, 280 +/- 34% of control; P < 0.001), anterior hypothalamic area (2-4 h, 252 +/- 42% of control; P < 0.01),dorsomedial nucleus (2-4 h, 368 +/- 29% of control; P < 0.001) and supraoptic nucleus (2-4 h, 212 +/- 34% of control; P < 0.05) of the hypothalamus. Administration of cocaine- and amphetamine-regulated transcript-(55-102) into the third ventricle of the hypothalamus resulted in an inhibition in feeding [0-4 h (0.4 nmol), 33 +/- 13% control; P < 0.001], but was associated with marked abnormalities in behavior, which may have interfered with feeding. These behavioral abnormalities were not observed after the administration of cocaine- and amphetamine-regulated transcript-(55-102) directly into the arcuate nucleus. These data suggest that cocaine- and amphetamine-regulated transcript may play an orexigenic role in the hypothalamic feeding circuitry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:35:53