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Titolo:
Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans
Autore:
Haney, M; Ward, AS; Gerra, G; Foltin, RW;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Psychiat, New York State Psychiat Inst, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Ctr Studi Farmacotossicodipendenze, Azienda Unita Sanitaria Locale, Parma,Italy Ctr Studi Farmacotossicodipendenze Parma Italy aria Locale, Parma,Italy
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 64, anno: 2001,
pagine: 63 - 73
SICI:
0376-8716(20010901)64:1<63:NEODAB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL EXTRACELLULAR DOPAMINE; SEROTONERGIC FUNCTION; NUCLEUS-ACCUMBENS; INTRAVENOUS COCAINE; ANTERIOR-PITUITARY; DEPENDENT PATIENTS; UNLIMITED-ACCESS; WITHDRAWAL; ABSTINENCE; PROLACTIN;
Keywords:
cocaine withdrawal; prolactin; cortisol; serotonin; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Haney, M Columbia Univ Coll Phys & Surg, Dept Psychiat, New York State Psychiat Inst, 1051 Riverside Dr,120, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 1051 Riverside Dr,120 New York NY USA 10032
Citazione:
M. Haney et al., "Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans", DRUG AL DEP, 64(1), 2001, pp. 63-73

Abstract

To study the consequences of repeated smoked cocaine use on central serotonergic and dopaminergic function, the effects of d-fenfluramine (d-FEN) andbromocriptine on plasma hormones were determined at three time-points following repeated cocaine self-administration under carefully controlled conditions. In a 20-day inpatient study, male cocaine abusers (d-FEN: n = 10; bromocriptine: n = 8) self-administered smoked cocaine (12-50 mg) for 3 days followed by 2 weeks of abstinence. The acute effects of d-FEN (0 or 30 mg po) or bromocriptine (0 or 1.25 mg po) on plasma neuroendocrine levels were determined 1-2, 7-8, and 13-14 days after the last cocaine dose. Blood was drawn before and then every 30-60 min for 4 h after capsule administration. The effects of d-FEN and bromocriptine were also determined in healthy, outpatient controls, d-FEN was removed from medical use in the US midway through the study due to complications associated with chronic administration, so all of the control participants were tested in Italy. Cocaine users had a blunted prolactin and cortisol response to d-FEN that lasted for at least2 weeks of cocaine abstinence, but had a normal response to bromocriptine,which suppressed prolactin by 50% of baseline. The long-lasting and selective disruptions in serotonin pathways following chronic cocaine use may provide a neurochemical basis for changes in mood commonly reported during cocaine withdrawal. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:48:33