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Titolo:
Relationship between blood flow kinetics and severity of Alzheimer's disease: Assessment of severity using a questionnaire-type examination, Alzheimer's disease assessment scale, cognitive sub-scale (ADAS(cog))
Autore:
Nebu, A; Ikeda, M; Fukuhara, R; Shigenobu, K; Maki, N; Hokoishi, K; Komori, K; Yasuoka, T; Tanabe, H;
Indirizzi:
Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 5, volume: 12, anno: 2001,
pagine: 318 - 325
SICI:
1420-8008(200109/10)12:5<318:RBBFKA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; TECHNETIUM-99M-HMPAO SPECT; DEMENTIA; PERFUSION; PET; ABNORMALITIES; METABOLISM; DIAGNOSIS; HMPAO;
Keywords:
Alzheimer's disease; hemokinetics; severity evaluation; Alzheimer's Disease Assessment Scale, cognitive sub-scale (ADAS(cog)); question-based examinations; Tc-99m-HM-PAO SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, M Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 u, Ehime 7910295, Japan
Citazione:
A. Nebu et al., "Relationship between blood flow kinetics and severity of Alzheimer's disease: Assessment of severity using a questionnaire-type examination, Alzheimer's disease assessment scale, cognitive sub-scale (ADAS(cog))", DEMENT G C, 12(5), 2001, pp. 318-325

Abstract

We assessed hemokinetics associated with changes in Alzheimer's disease (AD) severity in 90 AD patients by researching the relationship between AD Assessment Scale, cognitive sub-scale (ADAS(cog)) scores and regional cerebral blood flow (rCBF). In the present study, we employed the questionnaire-type ADAS(cog) examination to accurately assess the severity of AD. Between five groups classified on the basis of ADAS(cog) score, significant differences were observed in parietal, lateral temporal and superior frontal rCBF. In addition, in parietal and lateral temporal regions, significant correlations were also observed between ADAS(cog) score and rCBF. In superior frontal rCBF, significant differences were noted only between group 5 (greater than or equal to 40 ADAS(cog) points) and each of the other groups; there was no significant correlation between rCBF and ADAS(cog) score. Thus, we propose the following mechanism for blood flow kinetics associated with changed severity: In an early stage of AD, blood flow in the medial temporal cortex is impaired, and gradually involves the temporoparietal regions. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 20/06/19 alle ore 17:03:18