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Titolo:
The role of glial cells in Parkinson's disease
Autore:
Vila, M; Jackson-Lewis, V; Guegan, C; Wu, DC; Teismann, P; Choi, DK; Tieu, K; Przedborski, S;
Indirizzi:
Columbia Univ, Dept Neurol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Neurol, New York, NY 10032 USA Columbia Univ, Dept Pathol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Pathol, New York, NY 10032 USA
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 483 - 489
SICI:
1350-7540(200108)14:4<483:TROGCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; SUBSTANTIA-NIGRA; DOPAMINERGIC-NEURONS; NEUROTROPHIC FACTOR; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; CEREBROSPINAL-FLUID; INJURED STRIATUM; APOPTOTIC DEATH; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Przedborski, S BB307 Columbia Univ, 650 W 168th St, New York, NY 10032 USABB307 Columbia Univ 650 W 168th St New York NY USA 10032 SA
Citazione:
M. Vila et al., "The role of glial cells in Parkinson's disease", CURR OP NEU, 14(4), 2001, pp. 483-489

Abstract

Parkinson's disease is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta. The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, ofreactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Aside from these beneficial effects, the glial response can mediate a variety of deleterious events related to the production of reactive species, and pro-inflammatory prostaglandin and cytokines. This article reviews the potential protective and deleterious effects of glial cells in the substantia nigra pars compacta of Parkinson's disease. Curr Opin Neurol 14:483-489. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:19:10