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Titolo:
Parkin and Parkinson's disease
Autore:
Mizuno, Y; Hattori, N; Mori, H; Suzuki, T; Tanaka, K;
Indirizzi:
Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 eurol, Bunkyo Ku, Tokyo 1138421, Japan Tokyo Metropolitan Inst Med Sci, Tokyo 113, Japan Tokyo Metropolitan Inst Med Sci Tokyo Japan 113 ed Sci, Tokyo 113, Japan
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 477 - 482
SICI:
1350-7540(200108)14:4<477:PAPD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; UBIQUITIN-PROTEIN LIGASE; ALPHA-SYNUCLEIN; MESSENGER-RNA; EARLY-ONSET; GENE; MUTATIONS; EXPRESSION; CLONING; POLYMORPHISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mizuno, Y Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 yo 1138421, Japan
Citazione:
Y. Mizuno et al., "Parkin and Parkinson's disease", CURR OP NEU, 14(4), 2001, pp. 477-482

Abstract

Parkin is the causative gene for an autosomal recessive form of Parkinson's disease. The gene was discovered in 1998. The parkin gene is a novel genecontaining 12 exons spanning over 1.5 Mb and encodes a protein of 465 amino acids with a molecular mass of approximately 52000 Mr. Various deletion mutations and point mutations have been discovered in patients with autosomal recessive Parkinson's disease. The substantia nigra and the locus coeruleus selectively undergo neurodegeneration without forming Lewy bodies. The parkin gene product, Parkin protein, has a unique structure with a ubiquitin-like domain in the amino-terminus and a RING finger motif in the carboxy terminus. The function of Parkin was not known until recently. During the year 2000, great progress was made in defining its function. First of all, Parkin was found to be a ubiquitin-protein ligase (E3), a component of the ubiquitin system, which is an important adenosine triphosphate-dependent protein degradation machinery. In addition, CDCrel-1, a synaptic vesicle associated protein, was found to be a substrate for Parkin as an E3. Although many studies still need to be performed to elucidate the molecular mechanism of the selective nigral neurodegeneration in this form of familial Parkinson's disease, it will not be too long before this is accomplished. In this review article, we evaluate the developments in this area published since 1 February 2000. Curr Opin Neurol 14:477-482. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 18:06:01