Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The genetics of late-onset Alzheimer's disease
Autore:
Myers, AJ; Goate, AM;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 433 - 440
SICI:
1350-7540(200108)14:4<433:TGOLAD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-RELATED PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E; BETA-PROTEIN; APOE GENE; ALPHA-2-MACROGLOBULIN GENE; TRANSGENIC MICE; MOUSE MODEL; RISK; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Goate, AM Washington Univ, Sch Med, Dept Psychiat, B8134,660 S Euclid, St Louis, MO 63110 USA Washington Univ B8134,660 S Euclid St Louis MO USA 63110 110 USA
Citazione:
A.J. Myers e A.M. Goate, "The genetics of late-onset Alzheimer's disease", CURR OP NEU, 14(4), 2001, pp. 433-440

Abstract

Of late-onset Alzheimer's disease patients 50% do not carry an apolipoprotein E epsilon4 allele, indicating that there must be other genetic or environmental risk factors for the disease. During the past few years, both genetic linkage and candidate gene studies have been undertaken in order to identify novel genetic risk factors for late-onset Alzheimer's disease. Previous genome screens implicated a region of chromosome 12 that contains the genes that encode both alpha (2)-macroglobulin and the low-density lipoprotein receptor-related protein. However, candidate gene studies have produced mixed results with respect to both of these genes. New linkage studies now provide strong evidence for Alzheimer's disease susceptibility loci on chromosomes 9 and 10. The locus on chromosome 10 very probably modifies risk forAlzheimer's disease by modulating beta -amyloid-42 levels. Curr Opin Neurol 14:433-440. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:21:49