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Titolo:
Microtubule-stabilizing agents: a growing class of important anticancer drugs
Autore:
Altmann, KH;
Indirizzi:
Novartis Pharma AG, Corp Res, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
CURRENT OPINION IN CHEMICAL BIOLOGY
fascicolo: 4, volume: 5, anno: 2001,
pagine: 424 - 431
SICI:
1367-5931(200108)5:4<424:MAAGCO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-PRODUCTS; ANTITUMOR-ACTIVITY; EPOTHILONE-B; TUBULIN POLYMERIZATION; ANTIMITOTIC SUBSTANCE; BIOLOGICAL PROPERTIES; PACLITAXEL TAXOL(R); DESOXYEPOTHILONE-B; PURIFIED TUBULIN; CELL-LINES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Altmann, KH Novartis Pharma AG, Corp Res, WKL-136-5-22, CH-4002 Basel, Switzerland Novartis Pharma AG WKL-136-5-22 Basel Switzerland CH-4002 and
Citazione:
K.H. Altmann, "Microtubule-stabilizing agents: a growing class of important anticancer drugs", CURR OP C B, 5(4), 2001, pp. 424-431

Abstract

Microtubule-stabilizing agents continue to play an important role in anticancer drug discovery and development. New agents were again discovered in the past year, including small synthetic molecules. At least three new taxanes and two compounds of the epothilone class of natural products underwent clinical trials in 2000. Unexpected new findings about synergistic effects between different microtubule-stabilizing agents in vitro raise new prospects for combination chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:25:36