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Titolo:
Protein tyrosine phosphatases: prospects for therapeutics
Autore:
Zhang, ZY;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx, NY 10461USA
Titolo Testata:
CURRENT OPINION IN CHEMICAL BIOLOGY
fascicolo: 4, volume: 5, anno: 2001,
pagine: 416 - 423
SICI:
1367-5931(200108)5:4<416:PTPPFT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MYOCLONUS EPILEPSY; STRUCTURAL BASIS; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; SUBSTRATE-SPECIFICITY; MYOTUBULAR MYOPATHY; INSULIN SENSITIVITY; SIGNAL-TRANSDUCTION; LIPID 2ND-MESSENGER; TARGETED DISRUPTION; TUMOR-SUPPRESSOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, ZY Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med 1300 Morris Pk Ave Bronx NY USA 10461
Citazione:
Z.Y. Zhang, "Protein tyrosine phosphatases: prospects for therapeutics", CURR OP C B, 5(4), 2001, pp. 416-423

Abstract

Protein tyrosine phosphatases (PTPs) form a large family of enzymes that serve as key regulatory components in signal transduction pathways. Recent gene knockout studies in mice identify PTP1B as a promising target for anti-diabetes/obesity drug discovery. PTPs are also implicated in a wide varietyof other disorders, including cancer. Significant progress has been made in identifying small molecules that simultaneously bind both the active siteand a unique adjacent site that enables specific inhibition of individual PTP isoenzymes. As a consequence, there are compelling reasons to believe that PTP inhibitors may ultimately serve as powerful therapeutic weapons in our arsenal for battling human diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:05:20