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Titolo:
Dopamine: Biphasic dose responses
Autore:
Calabrese, EJ;
Indirizzi:
Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 m Hlth Sci, Amherst, MA 01003 USA
Titolo Testata:
CRITICAL REVIEWS IN TOXICOLOGY
fascicolo: 4-5, volume: 31, anno: 2001,
pagine: 563 - 583
SICI:
1040-8444(2001)31:4-5<563:DBDR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE RECEPTOR AGONISTS; BRAIN ADENYLATE-CYCLASE; PROLACTIN SECRETION; PREFRONTAL CORTEX; INDUCED RELAXATION; MOUSE-BRAIN; CA2+-DEPENDENT REGULATION; LOCOMOTOR-ACTIVITY; WORKING-MEMORY; AGED MONKEYS;
Keywords:
dopamine; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Calabrese, EJ Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 herst, MA 01003 USA
Citazione:
E.J. Calabrese, "Dopamine: Biphasic dose responses", CR R TOXIC, 31(4-5), 2001, pp. 563-583

Abstract

The present article indicates that dopamine and/or its agonists induce biphasic dose-response relationships for numerous endpoints. These include locomotion, pain sensitivity, blood pressure, prolactin secretion, oxytocin release, heart rate, memory, and neuronal adenylate cyclase activity. Biphasic responses were reported predominantly with male Sprague-Dawley rats, but also with mice, dogs, monkeys, and humans. Regardless of the model or endpoint the maximum changes from the control were always modest being within the 10 to 80% range. The range of stimulatory responses was quite variable, extending from slightly greater than a factor of 10 for the endpoints such as memory, pain-vocalization, and diastolic blood pressure to the lob range for prolactin release and the 10(8) range for oxytocin release. Mechanisticstudies suggested that the stimulatory and inhibitory effects of dopamine are mediated by different receptors or receptor subtypes having opposite actions and different ligand affinities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:49:15