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Titolo:
Adrenergic receptors: Biphasic dose responses
Autore:
Calabrese, EJ;
Indirizzi:
Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 m Hlth Sci, Amherst, MA 01003 USA
Titolo Testata:
CRITICAL REVIEWS IN TOXICOLOGY
fascicolo: 4-5, volume: 31, anno: 2001,
pagine: 523 - 538
SICI:
1040-8444(2001)31:4-5<523:ARBDR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; POSTSYNAPTIC ALPHA-ADRENOCEPTOR; SEXUAL-BEHAVIOR; BLOOD-PRESSURE; AGED RATS; PHARMACOLOGICAL CHARACTERIZATION; ALPHA-2-ADRENERGIC RECEPTORS; INTRATHECAL MORPHINE; ANTAGONISTS; YOHIMBINE;
Keywords:
adrenergic; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Calabrese, EJ Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 herst, MA 01003 USA
Citazione:
E.J. Calabrese, "Adrenergic receptors: Biphasic dose responses", CR R TOXIC, 31(4-5), 2001, pp. 523-538

Abstract

Agonists and antagonists of the adrenergic receptor system were assessed for their capacity to affect dose-response relationships across biological model, tissue and endpoint. U shaped dose responses were commonly reported, affecting multiple endpoints such as smooth muscle contraction/relaxation, memory, blood pressure, sexual behavior, platelet aggregation, and others. In six of the endpoints studied, mechanistic foundations of the biphasic nature of the dose response were established. The quantitative features of the dose-response relationships indicated that the maximum stimulatory responses, with but one exception, were less than twofold greater than the controls. The range of stimulatory responses was generally within 10- to 1000-fold, except for the platelet aggregation endpoint where the range was 10(3) to 10(5).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:15:31