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Titolo:
Overcompensation stimulation: A mechanism for hormetic effects
Autore:
Calabrese, EJ;
Indirizzi:
Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 m Hlth Sci, Amherst, MA 01003 USA
Titolo Testata:
CRITICAL REVIEWS IN TOXICOLOGY
fascicolo: 4-5, volume: 31, anno: 2001,
pagine: 425 - 470
SICI:
1040-8444(2001)31:4-5<425:OSAMFH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHYLCHOLINE AZIRIDINIUM ION; DEVELOPMENTAL CONVERSION; AXONAL DEGENERATION; ANGIOTENSIN-II; ANIMAL-MODELS; LEAD TOXICITY; NITRIC-OXIDE; TIME-COURSE; RAT; NEURONS;
Keywords:
hormesis; compensation; overcompensation; U-shaped responses; temporal effects; stimulatory effects; inhibitory effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Calabrese, EJ Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 herst, MA 01003 USA
Citazione:
E.J. Calabrese, "Overcompensation stimulation: A mechanism for hormetic effects", CR R TOXIC, 31(4-5), 2001, pp. 425-470

Abstract

Whether hormetic responses result from a direct or an overcompensation type of stimulatory response has been an unresolved and contentious issue in both radiation and chemical toxicology. The goal of the present article is to identify numerous examples of overcompensation stimulation in the biological/biomedical literature and to evaluate their descriptive and quantitative features. The findings provide support for the hypothesis that hormetic dose-response relationships from a broad array of biological models can occur after an initial disruption in homeostasis. The finding also demonstratesthe significant role of temporal factors in the assessment of dose response relationships.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:10:55