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Titolo:
Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Autore:
Nagase, H; Agematsu, K; Kitano, K; Takamoto, M; Okubo, Y; Komiyama, A; Sugane, K;
Indirizzi:
Shinshu Univ, Grad Sch Med, Dept Immunol & Infect Dis, Inst Organ Transplantat, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan3908621 sumoto, Nagano 3908621, Japan Shinshu Univ, Sch Med, Dept Internal Med 1, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 100, anno: 2001,
pagine: 250 - 259
SICI:
1521-6616(200108)100:2<250:MOHBHI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-CELLS; T-CELLS; CD27/CD70 INTERACTION; VIRUS HIV; IN-VITRO; ACTIVATION; CD27; DIFFERENTIATION; INTERLEUKIN-6; INDIVIDUALS;
Keywords:
CD27; CD70; memory B cells; HIV; hypergammaglobulinemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Agematsu, K Shinshu Univ, Grad Sch Med, Dept Immunol & Infect Dis, Inst Organ Transplantat, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan Shinshu Univ Asahi 3-1-1 Matsumoto Nagano Japan 3908621 Japan
Citazione:
H. Nagase et al., "Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis", CLIN IMMUNO, 100(2), 2001, pp. 250-259

Abstract

The mechanism of hypergammaglobulinemia in patients infected with HIV has remained unclear in spite of the identification of a reduction of CD4(+) T cells. The amounts of CD27(+) memory B cells were remarkably reduced in theperipheral blood and immunoglobulin (Ig) production was diminished in HIV-infected patients. Some of the freshly isolated patients' T cells expressedthe CD70 (CD27 ligand) on the surface and the CD70 expression on both of the CD4(+) and CD8(+) T cells was greatly enhanced by various stimuli. It was also striking that plasmacytosis was observed in patients' bone marrow. Thus, our findings suggest that CD70 expressed spontaneously or by activation on T cells of HIV-infected patients stimulates memory B cells via CD27 and promotes their differentiation into plasma cells, resulting in the elevation of serum Ig levels and the elimination of circulating memory B cells inHIV-infected patients. (C) 2001 Academic Press.

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Documento generato il 27/01/20 alle ore 07:42:43