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Titolo:
Simultaneous presence of mucous membrane pemphigoid and pemphigus vulgaris: Molecular characterization of both autoantibodies
Autore:
Sami, N; Bhol, KC; Beutner, EH; Plunkett, RW; Leiferman, KM; Foster, CS; Ahmed, AR;
Indirizzi:
Harvard Sch Dent Med, Dept Oral Med, Boston, MA 02115 USA Harvard Sch DentMed Boston MA USA 02115 t Oral Med, Boston, MA 02115 USA New England Baptist Hosp, Dept Med, Boston, MA 02115 USA New England Baptist Hosp Boston MA USA 02115 pt Med, Boston, MA 02115 USA Beutner Labs, Buffalo, NY 14215 USA Beutner Labs Buffalo NY USA 14215Beutner Labs, Buffalo, NY 14215 USA Mayo Clin, Immunodermatol Lab, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 unodermatol Lab, Rochester, MN 55905 USA Mass Eye & Ear Infirm, Boston, MA 02114 USA Mass Eye & Ear Infirm Boston MA USA 02114 ar Infirm, Boston, MA 02114 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 100, anno: 2001,
pagine: 219 - 227
SICI:
1521-6616(200108)100:2<219:SPOMMP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; COEXISTENCE; ANTIBODIES; THERAPY; SCLERODERMA; MYASTHENIA; SUBCLASS; FEATURES;
Keywords:
dual diagnosis; pemphigus; pemphigoid; indirect immunofluorescence; salt split skin; immunoblot analysis; IgG subclass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sami, N Harvard Sch Dent Med, Dept Oral Med, Boston, MA 02115 USA Harvard Sch Dent Med Boston MA USA 02115 ed, Boston, MA 02115 USA
Citazione:
N. Sami et al., "Simultaneous presence of mucous membrane pemphigoid and pemphigus vulgaris: Molecular characterization of both autoantibodies", CLIN IMMUNO, 100(2), 2001, pp. 219-227

Abstract

There are several reports in the literature describing the coexistence of features of pemphigus vulgaris and pemphigoid in the same patient. We describe 15 patients with clinical, histological, and immunopathological features of mucous membrane (cicatricial) pemphigoid at the time of initial diagnosis. All 15 patients failed to respond clinically to conventional systemic agents over a mean period of 7.2 years. Hence, IVIg therapy was used. Priorto initiating Mg therapy, features of mucous membrane pemphigoid and pemphigus vulgaris were demonstrated by various serological tests. Different assays were performed to identify molecular characteristics of these two autoantibodies. Twenty-five healthy normal individuals, 22 patients with mucous membrane pemphigoid, 17 patients with pemphigus vulgaris, and 12 patients with pemphigus foliaceus served as controls for comparison of serological studies. On indirect immunofluorescence, using monkey esophagous as substrate, sera of all 15 patients had demonstrable levels of anti-intercellular cement substance (ICS) or anti-keratinocyte cell surface antibody. Sera of 14 patients on salt split skin bound to the epidermal side of the split, whichwas consistent with mucous membrane pemphigoid. Sera of all 15 patients demonstrated binding to a 205-kDa protein (human B4 integrin) and a 130-kDa protein (desmoglein 3) on immunoblot. In a sample of sera from each of the 6patients with mucous membrane pemphigoid and pemphigus vulgaris, the anti-ICS antibody was of the IgG4 subclass. The IgG4 subclass is a characteristic feature associated with pathogenic autoantibodies in pemphigus vulgaris. Hence, in such patients, a dual diagnosis should be considered and confirmed by various serological assays. It is possible that the presence of two pathogenic autoantibodies in these patients could have contributed to the lack of response to conventional immunosuppressive therapy. (C) 2001 Academic Press.

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Documento generato il 17/01/21 alle ore 17:42:21