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Titolo:
TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells
Autore:
Pakala, SV; Ilic, A; Chen, LP; Sarvetnick, N;
Indirizzi:
Scripps Clin & Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Clin& Res Inst La Jolla CA USA 92037 nol, La Jolla, CA 92037 USA Mayo Clin, Dept Immunol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 n, Dept Immunol, Rochester, MN 55905 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 100, anno: 2001,
pagine: 198 - 207
SICI:
1521-6616(200108)100:2<198:TR1(OI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOBESE DIABETIC MICE; NECROSIS-FACTOR-ALPHA; HERPESVIRUS ENTRY MEDIATOR; DOMAIN-CONTAINING RECEPTOR; LYMPHOTOXIN-BETA-RECEPTOR; NOD MICE; TRANSGENIC MICE; TUMOR; APOPTOSIS; INSULITIS;
Keywords:
autoimmunity; diabetes; TNF-alpha receptor; T cells; LIGHT; HVEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pakala, SV Scripps Clin & Res Inst, Dept Immunol, 10550 N Torrey Pines Rd,La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
S.V. Pakala et al., "TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells", CLIN IMMUNO, 100(2), 2001, pp. 198-207

Abstract

Insulin-dependent diabetes mellitus results from T-cell-mediated destruction of pancreatic islet beta cells. Both CD4 and CD8 T cells have been shownto be independently capable of beta cell destruction. However, the mechanism of beta cell destruction has remained elusive. It has previously been shown that the absence of TNF-alpha receptor 1 (p55) on the islets protected islets from CD4 T-cell-mediated destruction as long as the T cells did not have access to wild-type islets in vivo. Wild-type and TNF-alpha receptor 1(p55) deficient islets induce similar levels of proliferation of BDC2.5 T cells. In this study, we demonstrate that islet TNF-alpha receptor I (p55) influences the expression of LIGHT (TNFSF-14), a TNF family member with both cytolytic and costimulatory properties, on BDC2.5 T cells and the expression of its receptor HVEM (TNFRSF-14) by islets, indicating a role for LIGHT-HVEM interactions in autoimmune diabetes. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:37:07