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Titolo:
Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: Caveat emptor and primum non nocere
Autore:
Greiner, DL; Rossini, AA; Mordes, JP;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 pt Med, Worcester, MA 01655 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 100, anno: 2001,
pagine: 134 - 143
SICI:
1521-6616(200108)100:2<134:TDFAMI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALMETTE-GUERIN VACCINATION; BOVINE SERUM-ALBUMIN; KILHAM RAT VIRUS; BB WISTAR RATS; ORAL INSULIN; BETA-CELL; BB/WOR RATS; HISTOCOMPATIBILITY COMPLEX; ISLET TRANSPLANTATION; SUSCEPTIBILITY GENES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Greiner, DL Diabet Div, Biotech 2, 373 Plantat St, Worcester, MA 01605 USADiabet Div 373 Plantat St Worcester MA USA 01605 MA 01605 USA
Citazione:
D.L. Greiner et al., "Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: Caveat emptor and primum non nocere", CLIN IMMUNO, 100(2), 2001, pp. 134-143

Abstract

Type 1 diabetes in humans is a serious autoimmune disorder of children that is still poorly understood unpreventable, and irreversible. Study of its animal models, notably the NOD mouse and BB rat, has generated a wealth of information concerning genetics and immunopathogenesis, but that information has still not altered the way in which we treat children with diabetes. In this review we attempt to identify the most promising avenues of continuing research in these models and the most important issues that must be faced by the designers of human therapies based on the animal dataset. (C) 2001Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:12:00