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Titolo:
Current clinical and laboratory strategies to augment the efficacy of immunotherapy in multiple myeloma
Autore:
Gorschluter, M; Ziske, C; Glasmacher, A; Schmidt-Wolf, IGH;
Indirizzi:
Univ Bonn, Med Klin & Poliklin 1, Dept Internal Med 1, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 ept Internal Med 1, D-53105 Bonn, Germany
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 8, volume: 7, anno: 2001,
pagine: 2195 - 2204
SICI:
1078-0432(200108)7:8<2195:CCALST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL TRANSPLANTATION; CYTOTOXIC T-LYMPHOCYTES; MEDIATED GENE-TRANSFER; BONE-MARROW TRANSPLANTATION; TUMOR-SPECIFIC RECOGNITION; COLONY-STIMULATING FACTOR; HIGH-DOSE CHEMOTHERAPY; GRAFT-VERSUS-LEUKEMIA; HUMAN PLASMA-CELLS; DENDRITIC CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt-Wolf, IGH Univ Bonn, Med Klin & Poliklin 1, Dept Internal Med 1, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 any
Citazione:
M. Gorschluter et al., "Current clinical and laboratory strategies to augment the efficacy of immunotherapy in multiple myeloma", CLIN CANC R, 7(8), 2001, pp. 2195-2204

Abstract

Multiple myeloma is still an incurable, lethal disease for the vast majority of patients. Myeloablative chemotherapy combined with autologous or allogeneic hematopoietic stem cell transplantation only partially met the greatexpectations initially set in its efficacy and is associated with a high level of toxicity. However, the considerable progress in understanding the biology of multiple myeloma led to the development of promising molecular therapies. Numerous immunotherapy-based approaches are currently evaluated inclinical trials. Moreover, remarkable progress has been achieved in gene therapy during the last decade, and the repertoire of gene transfer techniques can be expected to improve continuously. Gene transfer is increasingly applied in biological therapies in multiple myeloma. This article reviews the currently applied clinical and laboratory strategies to augment the efficacy of immunotherapy in multiple myeloma and aims to define its perspectives in multimodality treatment of multiple myeloma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:27:07