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Titolo:
Enhancement of heart rate variability by cholinergic stimulation with pyridostigmine in healthy subjects
Autore:
Nobrega, ACL; dos Reis, AF; Moraes, RS; Bastos, BG; Ferlin, EL; Ribeiro, JP;
Indirizzi:
Univ Fed Fluminense, Dept Physiol & Pharmacol, BR-24220111 Rio De Janeiro,Brazil Univ Fed Fluminense Rio De Janeiro Brazil BR-24220111 BCe Janeiro,Brazil Univ Fed Fluminense, Post Grad Program Cardiol, BR-24220111 Rio De Janeiro, Brazil Univ Fed Fluminense Rio De Janeiro Brazil BR-24220111 BC Janeiro, Brazil Hosp Clin Porto Alegre, Div Cardiol, Porto Alegre, RS, Brazil Hosp Clin Porto Alegre Porto Alegre RS Brazil , Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul, Sch Med, Dept Med, Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil Porto Alegre, RS, Brazil
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 1, volume: 11, anno: 2001,
pagine: 11 - 17
SICI:
0959-9851(200102)11:1<11:EOHRVB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CARDIAC VAGAL TONE; SUDDEN-DEATH; VENTRICULAR-TACHYCARDIA; TRANSDERMAL SCOPOLAMINE; CONTROLLED TRIAL; NERVOUS-SYSTEM; FAILURE; MORTALITY; EXERCISE;
Keywords:
autonomic; cholinergic; heart disease; parasympathetic; pyridostigmine; vagal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Nobrega, ACL Univ Fed Fluminense, Dept Physiol & Pharmacol, Rua Prof Hernani Melo 101,,BR-24220111 Rio De Janeiro, Brazil Univ Fed Fluminense Rua Prof Hernani Melo 101, Rio De Janeiro Brazil BR-24220111 BC
Citazione:
A.C.L. Nobrega et al., "Enhancement of heart rate variability by cholinergic stimulation with pyridostigmine in healthy subjects", CLIN AUTON, 11(1), 2001, pp. 11-17

Abstract

The purpose of this study was to determine the effect of the oral administration of pyridostigmine bromide on indices of heart rate variability (HRV)in healthy young volunteers. Seventeen healthy participants (11 men, 6 women, aged 27 +/- 8 y) submitted to a randomized, crossover, double-blind protocol, in which they received 30 mg pyridostigmine bromide (PYR) or placeboorally at 8-hour intervals for 24 hours, on two separate days. Venous blood samples were collected 2 and 24 hours after the first dose for determination of serum cholinesterase activity. Holter tapes were recorded during the24-hour period and analyzed using a semiautomatic technique to evaluate time- and frequency-domain indices of HRV and to build three-dimensional return maps for later quantification. Symptoms were mild and occurred similarlyduring administration of PYR and placebo (p = 0.140). Serum cholinesteraseactivity was reduced by 15% at 2 hours (p = 0.013) and by 14% at 24 hours (p = 0.010) after the first dose of PYR, but not after administration of placebo. Pyridostigmine administration caused a significant increase in the mean 24-hour R-R interval (placebo: 814 +/- 20 nisec; PYR: 844 +/- 18 msec; p = 0.003) and in time-domain indices of HRV, such as the standard deviation of all R-R intervals (SDNN; placebo: 151 +/- 9 msec; PYR: 164 +/- 9 msec,p = 0.017), and the percentage of pairs of adjacent R-R intervals differing by more than 50 msec (pNN50; placebo: 12.8 +/- 1.8%, PYR: 13.9 +/- 1.5%; p = 0.029). Pyridostigmine had no significant effect on frequency-domain indices of HRV, but resulted in significant increase in P-2, a parasympathetic. index derived from the three-dimensional return map (placebo: 93 +/- 13 msec; PYR: 98 +/- 13 ms, p = 0.029). in conclusion, low-dose pyridostigminereduced mean heart rate and increased HRV during a 24-hour period in healthy young subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:44:20