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Titolo:
Isolated airways from current smokers are hyper-responsive to histamine
Autore:
Schmidt, DT; Jorres, RA; Ruhlmann, E; Rabe, KF;
Indirizzi:
Leiden Univ, Med Ctr, Dept Pulmonol, NL-2300 RC Leiden, Netherlands LeidenUniv Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Krankenhaus Grosshansdorf, Zentrum Pneumol & Thoraxchirurg, D-2070 Grosshansdorf, Germany Krankenhaus Grosshansdorf Grosshansdorf Germany D-2070 hansdorf, Germany
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 7, volume: 31, anno: 2001,
pagine: 1041 - 1047
SICI:
0954-7894(200107)31:7<1041:IAFCSA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW OBSTRUCTION; ANTI-IGE ANTIBODY; SMOOTH-MUSCLE; SERUM IGE; IMMUNOGLOBULIN-E; BRONCHIAL RESPONSIVENESS; PASSIVE SENSITIZATION; CIGARETTE SMOKERS; YOUNG-ADULTS;
Keywords:
smoking; IgE; airway smooth muscle; bronchial hyper-responsiveness; passive sensitization; asthma; COPD; human; in vivo; in vitro;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, DT Leiden Univ, Med Ctr, Dept Pulmonol, C3-P,POB 9600, NL-2300 RCLeiden, Netherlands Leiden Univ C3-P,POB 9600 Leiden Netherlands NL-2300 RC lands
Citazione:
D.T. Schmidt et al., "Isolated airways from current smokers are hyper-responsive to histamine", CLIN EXP AL, 31(7), 2001, pp. 1041-1047

Abstract

Background Epidemiological studies suggest that bronchial hyper-responsiveness (BHR) and elevated levels of serum IgE are more frequently found in current smokers than in ex-smokers. Objective Since elevated serum IgE is associated with BHR under both in vivo and in vitro conditions, we aimed to assess whether smoking affects BHR independently from IgE. Methods Lung resection material was obtained from 27 current smokers and 11 nonsmokers with low serum IgE (< 100 U/mL). Peripheral airways were cut into rings and incubated overnight in the presence (passively sensitized) orabsence (non-sensitized) of serum containing IgE levels above 250 U/mL. Isometric contractile responses to histamine were assessed in the organ bath. Results Compared with non-smokers, isolated airways from smokers showed significantly increased responses to histamine (P < 0.05, ANOVA). Passive sensitization enhanced responses in both groups by about the same amount (P < 0.05, both). Conclusions In patients with low serum IgE current smoking is associated with increased bronchial responsiveness to histamine in vitro, which can be further enhanced by passive sensitization. These findings suggest that bothsmoking and serum IgE contribute to nonspecific airway hyper-responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:53:48