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Titolo:
Opiate-sensitivity: clinical characteristics and the role of skin prick testing
Autore:
Nasser, SMS; Ewan, PW;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Sch Clin, Dept Med, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Med, Cambridge CB2 2QQ, England
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 7, volume: 31, anno: 2001,
pagine: 1014 - 1020
SICI:
0954-7894(200107)31:7<1014:OCCATR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELLS; RESPONSES; MORPHINE; CODEINE; HETEROGENEITY; ANAPHYLAXIS; URTICARIA; HISTAMINE; DRUGS;
Keywords:
anaphylaxis; asthma; opiate; morphine; pethidine; papaveretum; rhinitis; skin prick test; urticaria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ewan, PW Addenbrookes Hosp, Dept Allergy & Clin Immunol, Hills Rd, Cambridge CB2 2QQ, England Addenbrookes Hosp Hills Rd Cambridge England CB2 2QQ QQ, England
Citazione:
S.M.S. Nasser e P.W. Ewan, "Opiate-sensitivity: clinical characteristics and the role of skin prick testing", CLIN EXP AL, 31(7), 2001, pp. 1014-1020

Abstract

Background The value of skin prick testing in opiate-sensitive individualsis uncertain as opiates cause non-specific weals by direct degranulation of mast cells. Objective To define whether skin prick test (SPT) responses to opiates in opiate-sensitive individuals are different to those seen in the normal population and to describe the clinical characteristics of this group of subjects. Methods The SPT responses of eight opiate-sensitive subjects to morphine 10 mg/mL, pethidine (meperidine) 50 mg/mL and papaveretum 15.4 mg/mL at fourdifferent concentrations (undiluted, 1/10, 1/50 and 1/100) were compared with the responses of 100 (32 atopic) non-opiate-sensitive control subjects. Four of the opiate-sensitive subjects had a clinical history of asthma, rhinitis or urticaria on occupational exposure to morphine. One subject developed urticaria with codeine, one developed urticaria and asthma with morphine and diamorphine and two subjects reacted to intravenous papaveretum withanaphylaxis or urticaria. Five out of the eight cases had opiate sensitivity confirmed by single-blind placebo-controlled oral challenge. Results Skin prick tests to all three opiates were not significantly different when the eight opiate-sensitive subjects were compared with either theentire normal control group or the subgroup of 47 definite opiate-tolerantcontrols that had previously received opiates for clinical indications. Furthermore, there were no significant differences in size of opiate SPT responses between atopic and non-atopic control subjects. In the control subjects, there was a positive correlation in SPT weal size between the three opiates. Conclusion Skin prick testing is not useful in the diagnosis of opiate sensitivity and placebo-controlled challenge should be considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:31:03