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Titolo:
Immunotherapy with a calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study
Autore:
Leynadier, F; Banoun, L; Dollois, B; Terrier, P; Epstein, M; Guinnepain, MT; Firon, D; Traube, C; Fadel, R; Andre, C;
Indirizzi:
Hop Rothschild, F-75571 Paris, France Hop Rothschild Paris France F-75571 op Rothschild, F-75571 Paris, France Hop Louis Pasteur, Paris, France Hop Louis Pasteur Paris FranceHop Louis Pasteur, Paris, France Stallergenes SA, Sci & Med Dept, F-92183 Antony, France Stallergenes SA Antony France F-92183 & Med Dept, F-92183 Antony, France
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 7, volume: 31, anno: 2001,
pagine: 988 - 996
SICI:
0954-7894(200107)31:7<988:IWACPF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGEN IMMUNOTHERAPY; NASAL CHALLENGE; RAGWEED-POLLEN; HAY-FEVER; EFFICACY; RESPONSES; RHINITIS; RELEASE; SAFETY; SKIN;
Keywords:
allergic rhinitis; grass pollen; specific immunotherapy; skin prick test; nasal provocation test; specific IgE; specific IgG(4);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Andre, C Stallergenes SA, Sci & Med Dept, 6 Rue Alexis de Tocqueville, F-92183 Antony, France Stallergenes SA 6 Rue Alexis de Tocqueville Antony France F-92183
Citazione:
F. Leynadier et al., "Immunotherapy with a calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study", CLIN EXP AL, 31(7), 2001, pp. 988-996

Abstract

Background Calcium phosphate-adsorbed allergen extracts axe used for subcutaneous immunotherapy to avoid the use of aluminium adjuvants. Objectives A double-blind, placebo-controlled study was performed in orderto confirm the safety and assess the efficacy of a standardized five-grass-pollen extract adsorbed onto calcium phosphate for specific immunotherapy (IT). Methods Twenty-nine patients with seasonal rhinoconjunctivitis were randomized to receive either the active preparation (16 patients) or placebo (13 patients), in a 1-year study. During the increasing dose phase, an extract ranging from 0.1 IR per mi to 50 IR per ml was administered at a rate of one subcutaneous injection per week until a maintenance dose was reached. Thepatients were assessed by symptom diary and rescue medications during seasonal exposure and specific nasal and skin reactivity before and after IT. Immunological parameters (specific IgE and IgG(4) antibodies) were assessed before, during and after IT. Results The overall symptoms score (mean AUC) was not significantly different between the IT group and the placebo group during grass-pollen exposure(49.6 vs. 56, respectively). The total medication score (mean AUC) was significantly lower in the IT group than in the placebo group (11 vs. 41, P < 0.01, Mann-Whitney U-test). The cumulative symptom/medication score was significantly lower in the IT group than in the placebo group (64.5 vs. 102.3,P < 0.05, U-test). A significant increase in nasal reactivity threshold was observed after IT in the IT group (21.4 IR/mL before IT vs. 63.4 IR/mL after IT, P < 0.01, Wilcoxon), whereas no significant changes were observed in the placebo group (31.0 IR/mL before IT vs. 37.7 IR/mL after IT). IT induced a significant reduction in grass pollen cutaneous reactivity in the actively treated group (P < 0.001). A significant increase in serum-specific IgG4 antibody response was observed in the IT group (3.1% before IT vs. 10.1% after IT, P < 0.001). Nine patients in the IT group developed moderate immediate systemic reactions vs. two patients in the placebo group. Conclusion Specific immunotherapy with calcium phosphate-adsorbed standardized grass pollen extract was safe and effective for the treatment of patients with seasonal allergic rhinoconjunctivitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:36:34