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Titolo:
Abnormal longitudinal, base-to-apex myocardial perfusion gradient by quantitative blood flow measurements in patients with coronary risk factors
Autore:
Hernandez-Pampaloni, M; Keng, FYJ; Kudo, T; Sayre, JS; Schelbert, HR;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA90095 USA
Titolo Testata:
CIRCULATION
fascicolo: 5, volume: 104, anno: 2001,
pagine: 527 - 532
SICI:
0009-7322(20010731)104:5<527:ALBMPG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; LONG-TERM SMOKING; ENDOTHELIAL DYSFUNCTION; LOWERING THERAPY; N-13 AMMONIA; ATHEROSCLEROSIS; RESERVE; HUMANS; CHOLESTEROL; VASOMOTION;
Keywords:
blood flow; circulation; tomography; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Schelbert, HR Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, 10833 Leconte Ave,23-120 CHS,Box 173517, Los Angeles, CA 90095 USA Univ Calif Los Angeles 10833 Leconte Ave,23-120 CHS,Box 173517 Los Angeles CA USA 90095
Citazione:
M. Hernandez-Pampaloni et al., "Abnormal longitudinal, base-to-apex myocardial perfusion gradient by quantitative blood flow measurements in patients with coronary risk factors", CIRCULATION, 104(5), 2001, pp. 527-532

Abstract

Background-A longitudinal, base-to-apex myocardial perfusion gradient has been described in patients with coronary artery disease (CAD) and was attributed to diffuse coronary luminal narrowing. We asked whether an abnormal perfusion gradient also existed in patients without CAD but with coronary risk factors. We measured myocardial blood flow (MBF) with N-13-ammonia and PET at rest and during hyperemia in patients with coronary risk factors but without CAD. Methods and Results-Regional MBF was measured in absolute units with N-13-ammonia and PET at rest and during dipyridamole hyperemia in 36 patients with coronary risk factors (age, 55 +/- 10 years) and in 36 age-matched (age,53 +/- 10 years) and in 28 young (age, 25 +/- 5 years) normal subjects. MBF was determined globally, for each of the 3 coronary territories, and in the mid and mid-to-apical sections of the left ventricle (LV). Myocardial perfusion on qualitative analysis was normal at rest and during hyperemia, and no flow defects were present. MBF in absolute units was similar in the 3 coronary territories. However, hyperemic MBFs in the mid-to-apical LV section were lower than in the mid LV section in the "at-risk" group (2.04 +/- 0.61 versus 1.71 +/- 0.40 mL . min(-1) . g(-1); P<0.004) but not in the age-matched or in the young normal subjects. Conclusions-The abnormal longitudinal, base-to-apex perfusion gradient observed during dipyridamole MBF suggests the presence of a functional and/or structural alteration of the coronary circulation associated with coronary risk factors, possibly reflecting developing coronary atherosclerosis or preclinical CAD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:21:52