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Titolo:
Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?
Autore:
Gomes, CM; Le Gall, J; Xavier, AV; Teixeira, M;
Indirizzi:
Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2780156 Oeiras, Portugal UnivNova Lisboa Oeiras Portugal P-2780156 l, P-2780156 Oeiras, Portugal Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Biochem & Mol Biol, Athens, GA 30602 USA Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, P-2825114 Monte De Caparica, Portugal Univ Nova Lisboa Monte De Caparica Portugal P-2825114 Caparica, Portugal
Titolo Testata:
CHEMBIOCHEM
fascicolo: 7-8, volume: 2, anno: 2001,
pagine: 583 -
SICI:
1439-4227(20010803)2:7-8<583:CADFPH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SEQUENCE ALIGNMENT; ALTERNATIVE OXIDASE; DESULFOVIBRIO-GIGAS; ACTIVE-SITE; PLANT-MITOCHONDRIA; RUBRERYTHRIN; RUBREDOXIN; MODEL; VULGARIS; CENTERS;
Keywords:
iron; metalloenzymes; molecular evolution; oxidoreductases; oxygen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Gomes, CM Univ Nova Lisboa, Inst Tecnol Quim & Biol, Rua Quinta Grande 6,Apt 127, P-2780156 Oeiras, Portugal Univ Nova Lisboa Rua Quinta Grande 6,Apt127 Oeiras Portugal P-2780156
Citazione:
C.M. Gomes et al., "Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?", CHEMBIOCHEM, 2(7-8), 2001, pp. 583

Abstract

To fulfil the title hypothesis, such a protein would have to harbour a binuclear transition metal site that would allow the complete reduction of dioxygen to water, thus playing an important role in early oxygen defence mechanisms in primordial anaerobes. The hypothesis here raised is based on dataconcerning the oxygen reductase activity of the four-helix diiron protein rubrerythrin (see schematic picture), and on sequence- and structure-based phylogenetic relations between this and other diiron proteins. Interestingly, an evolutionary relationship between such an early system and the alternative oxidases present in extant eukaryotes can be depicted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:07:23