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Titolo:
Cytoskeletal mechanisms of neuronal degeneration
Autore:
Brandt, R;
Indirizzi:
Univ Heidelberg, IZN, Dept Neurobiol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 2, volume: 305, anno: 2001,
pagine: 255 - 265
SICI:
0302-766X(200108)305:2<255:CMOND>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEIN; AMYOTROPHIC-LATERAL-SCLEROSIS; PAIRED HELICAL FILAMENTS; TAU-ANTISENSE OLIGONUCLEOTIDES; SYNTHASE KINASE 3-BETA; CENTRAL NERVOUS-SYSTEM; HUMAN BRAIN TAU; ALZHEIMERS-DISEASE; TRANSGENIC MICE; MOTOR-NEURONS;
Keywords:
Alzheimer's disease; amyotrophic lateral sclerosis; cytoskeleton; tau protein; neurofilament;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Brandt, R Univ Heidelberg, IZN, Dept Neurobiol, Neuenheimer Feld 364, D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 364 Heidelberg Germany D-69120
Citazione:
R. Brandt, "Cytoskeletal mechanisms of neuronal degeneration", CELL TIS RE, 305(2), 2001, pp. 255-265

Abstract

The cytoskeleton is the major intracellular determinant of neuronal morphology and is required for fundamental processes during the development and maintenance of a neuron. Thus, it is not surprising that many neurodegenerative diseases including Alzheimer's disease and amyotrophic lateral sclerosis (motor neuron disease) are characterized by typical abnormalities in the organization of the cytoskeleton. However, the role of the cytoskeletal changes during the development of the disease, e.g., whether they have a causative role during neuronal degeneration or represent an epiphenomenon of neurons that degenerate by other means, is still disputed. In this review, recent results on the development and the role of cytoskeletal abnormalities during neurodegenerative diseases are discussed and a mechanistic framework for the involvement of cytoskeletal changes during neurodegenerative processes is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:50:13