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Titolo:
Molecular interactions between neurotrophin receptors
Autore:
Dechant, G;
Indirizzi:
Max Planck Inst Neurobiol, Dept Neurobiochem, D-82152 Martinsried, GermanyMax Planck Inst Neurobiol Martinsried Germany D-82152 rtinsried, Germany
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 2, volume: 305, anno: 2001,
pagine: 229 - 238
SICI:
0302-766X(200108)305:2<229:MIBNR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; RAT SYMPATHETIC NEURONS; CAVEOLAE-LIKE DOMAINS; SIGNAL-TRANSDUCTION; SENSORY NEURONS; PLASMA-MEMBRANE; TYROSINE KINASE; TRKB RECEPTORS; LIGAND-BINDING;
Keywords:
Trk; receptor tyrosine kinase; neurotrophins; p75; ceramide; alternative splicing; internalization; retrograde transport;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Dechant, G Max Planck Inst Neurobiol, Dept Neurobiochem, Klopferspitz 18A,D-82152 Martinsried, Germany Max Planck Inst Neurobiol Klopferspitz 18A Martinsried Germany D-82152
Citazione:
G. Dechant, "Molecular interactions between neurotrophin receptors", CELL TIS RE, 305(2), 2001, pp. 229-238

Abstract

Neurotrophins signal via a dual-receptor system comprising receptor tyrosine kinases, the Trks, and a tumor necrosis factor (TNF) receptor like molecule, p75. Interest in these receptors was spurred on by the finding that they are employed by their neurotrophin ligands to activate opposing cellularmechanisms. Signalling via Trk receptors promotes the survival of embryonic neurons, whereas activation of p75 can trigger apoptosis. However, this antagonistic view is an oversimplification. It is more accurate to refer to this system as a signalling network in which ligands, receptors and their intracellular target proteins are linked by balanced biochemical interactions. This article reviews recent advances in our understanding, of these molecular mechanisms which critically determine many cell-type-specific responses to neurotrophins. Emphasis is given to the formation of receptor complexes, the generation of receptor diversity by alternative splicing and the influence exerted by the local membrane environment on neurotrophin signalling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:37:21