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Titolo:
Efficacy and safety of imidapril in patients with essential hypertension: A double-blind comparison with captopril
Autore:
Huang, PJ; Chien, KL; Chen, MF; Lai, LP; Chiang, FT;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 10016, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 10016 Cardiol, Taipei 10016, Taiwan
Titolo Testata:
CARDIOLOGY
fascicolo: 3, volume: 95, anno: 2001,
pagine: 146 - 150
SICI:
0008-6312(2001)95:3<146:EASOII>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; CHRONIC HEART-FAILURE; INDUCED BRONCHOCONSTRICTION; ACE-INHIBITOR; SUBSTANCE-P; C-FIBERS; COUGH; STIMULATION;
Keywords:
imidapril; hypertension; captopril; angiotensin-converting enzyme inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, PJ Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, 7 Chuang Shan S Rd,Taipei 10016, Taiwan Natl Taiwan Univ Hosp 7 Chuang Shan S Rd Taipei Taiwan 10016 an
Citazione:
P.J. Huang et al., "Efficacy and safety of imidapril in patients with essential hypertension: A double-blind comparison with captopril", CARDIOLOGY, 95(3), 2001, pp. 146-150

Abstract

In this 12-week, double-blind, parallel-group, comparative trial, 57 adultpatients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twice if diastolic blood pressure (DBP) remained greater than or equal to 90 mm Hg. Both treatments effectively lowered DBP in a comparable manner. Mean changes from baseline in DBP at 12 weeks were -9.9 mm Hg for imidapril and -8.8 mm Hg for captopril (p = 0.488). Responder rates in patients receiving active treatment for at least 6 weeks were 53.9% for imidapril and 48% for captopril (p = 0.676). Both treatments were well tolerated. Adverse drug reactions were observed in 20.7% (6/29) of the imidaprilgroup and 46.4% (13/28) of the captopril group (p < 0.05). A cough was themost frequent side effect, reported in 13.8% of the imidapril group and 35.7% of the captopril group. The results indicate that imidapril is as effective as captopril in the treatment of hypertension. Imidapril produces lessadverse effects compared with captopril. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:38:38