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Titolo:
The association of kappa-ras gene mutation and vascular endothelial growthfactor gene expression in pancreatic carcinoma
Autore:
Ikeda, N; Nakajima, Y; Sho, M; Adachi, M; Huang, CI; Iki, K; Kanehiro, H; Hisanaga, M; Nakano, H; Miyake, M;
Indirizzi:
Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Thorac Surg, Kita Ku, Osaka5308480, Japan Kitano Hosp Osaka Japan 5308480 horac Surg, Kita Ku, Osaka5308480, Japan Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Oncol 5, Kita Ku, Osaka 5308480, Japan Kitano Hosp Osaka Japan 5308480 t Oncol 5, Kita Ku, Osaka 5308480, Japan Nara Med Univ, Dept Surg 1, Nara, Japan Nara Med Univ Nara JapanNara Med Univ, Dept Surg 1, Nara, Japan Kawasaki Med Univ, Dept Surg, Okayama, Japan Kawasaki Med Univ Okayama Japan aki Med Univ, Dept Surg, Okayama, Japan
Titolo Testata:
CANCER
fascicolo: 3, volume: 92, anno: 2001,
pagine: 488 - 499
SICI:
0008-543X(20010801)92:3<488:TAOKGM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-RAS; TUMOR ANGIOGENESIS; PERMEABILITY FACTOR; PROGNOSTIC-SIGNIFICANCE; DUCTAL ADENOCARCINOMA; ENHANCED EXPRESSION; ONCOGENE ACTIVATION; FACTOR FAMILY; CELL-LINES; CANCER;
Keywords:
K-ras; vascular endothelial growth factor; angiogenesis; pancreatic carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Miyake, M Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Thorac Surg, KitaKu, 13-3 Kamiyama Cho, Osaka 5308480, Japan Kitano Hosp 13-3 Kamiyama Cho Osaka Japan 5308480 308480, Japan
Citazione:
N. Ikeda et al., "The association of kappa-ras gene mutation and vascular endothelial growthfactor gene expression in pancreatic carcinoma", CANCER, 92(3), 2001, pp. 488-499

Abstract

Background. Previously, the authors reported the role of the vascular endothelial growth factor (VEGF) as an angiogenic factor in 40 patients with pancreatic carcinoma. In this study, they investigated the mechanism underlying the regulation of VEGF gene expression and evaluated EGF expression and K-ras gene status in 48 patients with pancreatic carcinoma. Methods. The authors used quantitative reverse transcriptase-polymerase chain reaction analysis and direct sequencing techniques for a retrospective study of VEGF gene expression and K-ras gene status in tumor tissue samplesfrom 48 patients with pancreatic carcinoma. Immunohistochemistry also was used to investigate VEGF protein expression. Results. Thirty-one tumors (64.6%) were evaluated with high VEGF expression, and 17 tumors (35.4%) were evaluated with low VEGF expression. Of the 48primary pancreatic tumors studied, 33 tumors (68.8%) contained mutations of the K-ras gene. There was a significant correlation between T-GF expression and K-ras status. Twenty-five of 33 tumors (75.8%) with mutant K-ras genes showed high VEGF expression, whereas only 6 of 15 tumors with the wild type K-ras (40.0%) showed high VEGF expression (P = 0.038). The mean (+/- standard error) VEGF conservation rate for the 33 tumors with mutant K-ras was 1.839 +/- 1.241, and that for the 15 tumors with wild type K-ras was 1.057 +/- 0.983 (P = 0.037). Furthermore, the median survival for patients withmutant K-ras was shorter than for those with wild type K-ras (10.6 months vs. 27.6 months, respectively; P = 0.026), whereas the median survival for patients with high VEGF expression was shorter compared with that for patients with low VEGF expression (9.5 months vs. 26.4 months, respectively; P =0.002). Cox regression model analysis indicated that only the VEGF status was a significant factor for prognosis (P = 0.024). Other variables, i.e., K-ras status, histopathologic tumor grade, tumor status, lymph node status,metastatic status, gender, and age at surgery, were not significant. Conclusions. The results of this study suggest that K-ras oncogene mutation may be associated with VEGF expression and that patients with pancreatic carcinoma who have high VEGF expression are associated with a poor prognosis. Cancer2001; 92:488-99. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:03:07