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Titolo:
DOSE-RELATED EFFECT OF INTRAVENOUS L-ARGININE ON MUSCULAR BLOOD-FLOW OF THE CALF IN PATIENTS WITH PERIPHERAL VASCULAR-DISEASE - A H-2 O-15 POSITRON EMISSION TOMOGRAPHY STUDY
Autore:
SCHELLONG SM; BOGER RH; BURCHERT W; BODEBOGER SM; GALLAND A; FROLICH JC; HUNDESHAGEN H; ALEXANDER K;
Indirizzi:
UNIV CLIN DRESDEN,MED KLIN 2,FETSCHERSTR 74 D-01307 DRESDEN GERMANY HANNOVER MED SCH,DEPT ANGIOL D-30625 HANNOVER GERMANY HANNOVER MED SCH,DEPT CLIN PHARMACOL D-30625 HANNOVER GERMANY HANNOVER MED SCH,DEPT NUCL MED D-30625 HANNOVER GERMANY
Titolo Testata:
Clinical science
fascicolo: 2, volume: 93, anno: 1997,
pagine: 159 - 165
SICI:
0143-5221(1997)93:2<159:DEOILO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; NITRIC-OXIDE PRECURSOR; CYCLIC-GMP; HYPERCHOLESTEROLEMIC PATIENTS; ARTERIAL RESISTANCE; HUMANS; INFUSION; NITRATE; RELEASE; VESSELS;
Keywords:
L-ARGININE; CYCLIC GMP; NITRIC OXIDE; POSITRON EMISSION TOMOGRAPHY; SKELETAL MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Schellong et al., "DOSE-RELATED EFFECT OF INTRAVENOUS L-ARGININE ON MUSCULAR BLOOD-FLOW OF THE CALF IN PATIENTS WITH PERIPHERAL VASCULAR-DISEASE - A H-2 O-15 POSITRON EMISSION TOMOGRAPHY STUDY", Clinical science, 93(2), 1997, pp. 159-165

Abstract

1. Endothelium-derived nitric oxide (NO) contributes to the regulation of vascular tone and blood pressure. Infusion of L-arginine producessystemic vasodilatation via stimulation of endogenous NO formation. Vasodilatation is accompanied by an increase in peripheral arterial blood flow. However, it is not known whether capillary nutritive blood flow increases as well. The time course and dose-response pattern of this effect remain to be elucidated. 2. Two groups of ten patients with peripheral vascular disease (PVD) received an intravenous infusion of 8g or 30 g of L-arginine over a period of 40 min. Blood pressure and heart rate were monitored noninvasively. Muscular blood how (MBF) of the calf was determined at 0, 20, 40, 60, 80 min by positron emission tomography with (H2O)-O-15 as flow tracer. Plasma L-arginine and cyclic GMP (cGMP) levels were determined at the same time points. 3. L-arginine induced a dose-related decrease in blood pressure during the infusion period. MBF and plasma cGMP levels during and after the infusion of8 g of L-arginine did not change significantly. In the patients receiving 30 g of L-arginine, MBF was enhanced significantly from 1.56 +/- 0.14 to 2.09 +/- 0.21 ml min(-1) 100 ml(-1) at 40 min and 2.23 +/- 0.15 ml min(-1) 100 ml(-1) after 80 min (+ 43.0%). The increase in MBF was paralleled by an increase in plasma cGMP from 4789.8 +/- 392.2 nmol/l at baseline to 9223.2 +/- 1233.6 nmol/l at 40 min. 4. We conclude that intravenous L-arginine enhances nutritive capillary MBF in patientswith PVD via the NO-cGMP pathway in a dose-related manner. This effect might be therapeutically beneficial in patients with PVD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:15:58