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Titolo: Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia
Autore: MahieuCaputo, D; Sonigo, P; Dommergues, M; Fournet, JC; Thalabard, JC; Abarca, C; Benachi, A; Brunelle, F; Dumez, Y;
 Indirizzi:
 Necker Hosp Sick Children, Paris, France Necker Hosp Sick Children ParisFrance osp Sick Children, Paris, France
 Titolo Testata:
 BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 8,
volume: 108,
anno: 2001,
pagine: 863  868
 SICI:
 14700328(200108)108:8<863:FLVMBM>2.0.ZU;21
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 INUTERO; 3DIMENSIONAL ULTRASONOGRAPHY; ULTRASOUND DIAGNOSIS; PULMONARY HYPOPLASIA; PROGNOSTIC FACTORS; SURVIVAL; FETUSES;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Clinical Medicine
 Life Sciences
 Citazioni:
 25
 Recensione:
 Indirizzi per estratti:
 Indirizzo: MahieuCaputo, D Maternite Hop Necker Enfants Malades, 149 Rue Sevres, Paris, France Maternite Hop Necker Enfants Malades 149 Rue Sevres Paris France



 Citazione:
 D. MahieuCaputo et al., "Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia", BR J OBST G, 108(8), 2001, pp. 863868
Abstract
Objective To study the potential for prenatal magnetic resonance imaging to predict pulmonary hypoplasia in congenital diaphragmatic hernia. Design Prospective observational study. Setting Tertiary care centre. Participants Thirteen cases of congenital diaphragmatic hernia (11 left, 2right) without associated anomalies and 74 controls. Methods Measurements by magnetic resonance imaging of fetal lung volume were achieved. In the control fetuses, a regression analysis was performed toassociate fetal lung volume with gestational age. This yielded a formula allowing calculation of the expected fetal lung volume as a function of gestational age. In the cases with congenital diaphragmatic hernia, the observed/expected fetal lung volume ratio was compared with perinatal outcome. Main outcome measures Neonatal mortality and pulmonary hypoplasia, which was defined as lung/body weight ratios less than 0.012. C,Results The expected fetal lung volume was derived from the following formula: Fetal lung volume (mL) exp (1.24722 + 0.08939 X gestational age in weeks). The observed/expected fetal lung volume ratio was significantly lower in congenital diaphragmatic hernia (median: 0.31, range: 0.060.63), than in controls (median: 0.99, range: 0.421.94). This ratio was significantly less in the infants with congenital diaphragmatic hernia who died (median: 0.26, range: 0.060.63) compared with those who survived (median: 0.46, range: 0.350.56). The observed: expected fetal lung volume ratio was significantly correlated with the postmortem lung: body weight ratio. Conclusion In isolated conenital diaphragmatic hernia, fetal lung volume measurement by magnetic resonance C imaging is a potential predictor of pulmonary hypoplasia and postnatal outcome. Further studies are required C, toestablish the clinical value of macynetic resonance imaging for the prenatal assessment of fetal lungs.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:50:44