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Titolo:
Increased levels of interleukin-10 and transforming growth factor-beta in the plasma and ascitic fluid of patients with advanced ovarian cancer
Autore:
Santin, AD; Bellone, S; Ravaggi, A; Roman, J; Smith, CV; Pecorelli, S; Cannon, MJ; Parham, GP;
Indirizzi:
Univ Arkansas, Div Gynecol Oncol, UAMS Med Ctr, Dept Obstet & Gynaecol, Little Rock, AR 72204 USA Univ Arkansas Little Rock AR USA 72204 ynaecol, Little Rock, AR 72204 USA Univ Arkansas, Dept Microbiol & Immunol, Little Rock, AR USA Univ Arkansas Little Rock AR USA icrobiol & Immunol, Little Rock, AR USA Univ Brescia, Div Gynaecol Oncol, I-25121 Brescia, Italy Univ Brescia Brescia Italy I-25121 ynaecol Oncol, I-25121 Brescia, Italy
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 8, volume: 108, anno: 2001,
pagine: 804 - 808
SICI:
1470-0328(200108)108:8<804:ILOIAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOLOGOUS DENDRITIC CELLS; T-CELLS; SERUM INTERLEUKIN-10; IMMUNE-RESPONSES; MULTIPLE-MYELOMA; TUMOR-ANTIGEN; NK-CELLS; TGF-BETA; CARCINOMA; VACCINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Santin, AD Univ Arkansas, Div Gynecol Oncol, UAMS Med Ctr, Dept Obstet & Gynaecol, 4301 W Markham, Little Rock, AR 72204 USA Univ Arkansas 4301 W Markham Little Rock AR USA 72204 72204 USA
Citazione:
A.D. Santin et al., "Increased levels of interleukin-10 and transforming growth factor-beta in the plasma and ascitic fluid of patients with advanced ovarian cancer", BR J OBST G, 108(8), 2001, pp. 804-808

Abstract

Objectives To assess expression of the immunosuppressive cytokines IL-10 and TGF-beta in the ascitic fluid and plasma of advanced ovarian cancer patients. Design A prospective study. Setting The Department of Obstetrics and Gynaecology at the University of Arkansas for Medical Sciences. Population Twenty-eight women diagnosed with advanced ovarian cancer and ten normal female controls. Methods Plasma and ascitic samples were collected at the time of surgery and analysed for the presence of IL-10 and TGF-beta using a sensitive enzyme-linked immunosorbent assay. Results Elevated levels of IL-10 were detected in the plasma [mean (SD) = 12 (5) pg/mL; range 8 to 23 pg/mL] and in the, peritoneal fluid [mean (SD) = 165 (137) pg/mL; range 50 to 556 pg/mL] of ovarian cancer patients, whileno detectable IL-10 was found in any of the normal control plasma samples tested. Similarly, plasma levels of TGF-beta in ovarian cancer patients were significantly higher [mean (SD) = 1506 (246) pg/mL; range 1020 to 2070 pg/mL] compared with controls [mean (SD) = 937 (187) pg/mL; range 770 to 1140pg/mL](P < 0.001). Surprisingly, however, although elevated TGF-beta levels were also detected in the peritoneal fluid of all ovarian cancer patients[mean (SD) = 407 (158) pg/mL; range 140 to 770 pg/mL], these levels were significantly lower than those seen in matched plasma samples (P < 0.001). Conclusions Local and systemic secretion of immunosuppressive cytokines may play an important role in the impaired anti-tumour immune function commonly observed in advanced ovarian cancer. However, the observation that plasma levels of TGF-beta are significantly higher than those detected in the ascitic fluid raises the possibility that cells other than tumour cells are responsible for TGF-beta release in the bloodstream of these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:50:05