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Titolo:
Clinical diagnosis of influenza virus infection: evaluation of diagnostic tools in general practice
Autore:
van Elden, LJR; van Essen, GA; Boucher, CAB; van Loon, AM; Nijhuis, M; Schipper, P; Verheij, TJM; Hoepelman, IM;
Indirizzi:
Eijkman Winkler Inst Microbiol Infect Dis & Infla, Dept Virol, Utrecht, Netherlands Eijkman Winkler Inst Microbiol Infect Dis & Infla Utrecht Netherlands s Julius Ctr Gen Practice & Patient Oriented Res, Dept Gen Practice, Utrecht, Netherlands Julius Ctr Gen Practice & Patient Oriented Res Utrecht Netherlands ands Univ Med Ctr, Div Infect Dis, Utrecht, Netherlands Univ Med Ctr Utrecht Netherlands , Div Infect Dis, Utrecht, Netherlands Univ Med Ctr, AIDS Dept Internal Med, Div Infect Dis & AIDS, Utrecht, Netherlands Univ Med Ctr Utrecht Netherlands nfect Dis & AIDS, Utrecht, Netherlands
Titolo Testata:
BRITISH JOURNAL OF GENERAL PRACTICE
fascicolo: 469, volume: 51, anno: 2001,
pagine: 630 - 634
SICI:
0960-1643(200108)51:469<630:CDOIVI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAMINIDASE INHIBITOR OSELTAMIVIR; VIRAL-INFECTIONS; REVERSE-TRANSCRIPTION; SURVEILLANCE; COMMUNITY; CHILDREN; ENGLAND; WALES; PCR;
Keywords:
influenza; clinical diagnosis; antiviral drugs; polymerase chain reaction; virus culture; rapid culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: van Elden, LJR Herenstr 19, NL-3512 KE Utrecht, Netherlands Herenstr 19 Utrecht Netherlands NL-3512 KE t, Netherlands
Citazione:
L.J.R. van Elden et al., "Clinical diagnosis of influenza virus infection: evaluation of diagnostic tools in general practice", BR J GEN PR, 51(469), 2001, pp. 630-634

Abstract

Background: With the development of new antiviral agents for influenza, the urge for rapid and reliable diagnosis of influenza becomes increasingly important. Respiratory virus infections are difficult to distinguish on clinical grounds General practitioners (GPs) however still depend on their clinical judgement,Aim: To evaluate the importance of clinical symptoms in the diagnosis of influenza virus infection,Design of study: A multicentre questionnaire study. Setting: Eighty-one patients from 14 general practices. Method: Patients with fever and at least one constitutional symptom and one respiratory symptom were included. A questionnaire with the medical history and clinical symptoms was, completed and a combined nose-throat swab wastaken. Virus culture, rapid culture, and polymerase chain reaction (FCR) amplification, were performed on each specimen, Multivariate analysis was used to obtain the best predictive model,Results By using FCR, an increase was seen in the detection of the viral pathogens compared with the results of culture. in 42 out of 81 patients PCRwas positive for influenza. A positive predictive value (PPV) of 75% was observed for the combination of headache at onset, feverishness at onset, cough, and vaccination status during the period of increase influenza activity. Criteria used by the ICHPPC-2 resulted in a PPV of 54%. The PPV for diagnosis made by the GP was 76%. Conclusion: Although influenza is difficult to diagnose on clinical grounds, the GPs in this study were able to diagnose influenza as such more accurately on their judgement than by the other criteria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:07:51