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Titolo:
Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine
Autore:
Radu, D; Brodin, E; Weber, G; Lindefors, N;
Indirizzi:
Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ci, SE-17176 Stockholm, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Physiol & Pharmacol, Stockholm, Sweden Karolinska Inst, Ctr Mol Med, Stockholm, Sweden Karolinska Inst Stockholm Sweden a Inst, Ctr Mol Med, Stockholm, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 908, anno: 2001,
pagine: 197 - 203
SICI:
0006-8993(20010727)908:2<197:DSIITL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
YOHIMBINE-INDUCED RELEASE; FREELY MOVING RAT; SUBSTANCE-P; CEREBRAL-CORTEX; FRONTAL-CORTEX; MESSENGER-RNA; RESTRAINT STRESS; LIMBIC REGIONS; HUMAN-BRAIN; NEURONS;
Keywords:
brain; cholecystokinin; ketamine; microdialysis; prefrontal cortex; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Radu, D Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 7176 Stockholm, Sweden
Citazione:
D. Radu et al., "Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine", BRAIN RES, 908(2), 2001, pp. 197-203

Abstract

In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease 20 min after and an increase 8 h after mild stress. These changes seem to be region specific. Measurement of CCK mRNA in prefrontal cortex neurons 4 or 8 h after the stress stimulus did not reveal changes in mRNA levels, suggesting that afferent CCK-containing neuron terminals may be more affected than local cortical CCK-ergic neurons. Furthermore, treatment with the glutamate NMDA receptor antagonist ketamine, led to more pronounced decreases in CCK-LI observed within 20 min after mild stress and counteracted the stress induced increase in cortical CCK-LI levels observed at 8 h. Implantation of a microdialysis probe in the PFC affected the response to mild stress, with no significant decrease in the CCK-LI level 20 min after, and attenuated reactivity to stress 8 h after the saline injection. Our results indicate that a mild stressful stimulus such as an intraperitoneal saline injection may have long-lasting effects on CCK-ergic transmission in the PFC. The use of microdialysis to study stress induced in vivo CCK-LI release in awake animals may, however, be significantly compromised by the impact of the microdialysis probe implantation on CCK-ergic mechanisms in the PFC. In addition, we hypothesize that subanesthetic doses of the psychotomimetic drug ketamine interfere with CCK-ergic mechanisms in the PFC during stress. (C) 2001 Elsevier Science BV All rights reserved.

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Documento generato il 25/01/20 alle ore 16:09:32